American Journal of Epidemiology Vol. 155, No. 1 : 65-71
Copyright © 2002 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Associations of Serum C-reactive Protein with Fasting Insulin, Glucose, and Glycosylated Hemoglobin
The Third National Health and Nutrition Examination Survey, 1988–1994
From the Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY.
This study investigated the associations between serum C-reactive protein and fasting blood levels of insulin, glucose, and hemoglobin A1c (HbA1c). Data from the Third National Health and Nutrition Examination Survey (1998–1994) were used. Study subjects included 2,466 men and 2,876 women who were 
17 years and nondiabetics with an overnight fast for blood draw. C-reactive protein was categorized into low (<0.3 mg/dl), moderate (0.3–0.9 mg/dl), and high (1.0 mg/dl) levels. Mean levels of insulin, glucose, and HbA1c were compared across C-reactive protein levels after adjustment for age, ethnicity, education, poverty index, cigarette smoking, alcohol use, and leisure time physical activity. For men with low (n = 1,818), moderate (n = 493), and high (n = 155) C-reactive protein, the adjusted means of insulin were 9.4, 11.7, and 10.5 microunits/ml (p < 0.01); glucose, 99.8, 101.6, and 100.6 mg/dl (p > 0.05); and HbA1c, 5.4%, 5.5%, and 5.5% (p < 0.05). For women with low (n = 1,816), moderate (n = 776), and high (n = 282) C-reactive protein, the adjusted means of insulin were 8.7, 11.2, and 13.7 microunits/ml (p < 0.01); glucose, 95.3, 97.9, and 105.2 mg/dl (p < 0.01); and HbA1c, 5.3%, 5.4%, and 5.6% (p < 0.01). In conclusion, elevated C-reactive protein was associated with higher insulin and HbA1c among men and women and with higher glucose levels among women only. These results suggest a possible role of inflammation in insulin resistance and glucose intolerance.
C-reactive protein; glucose; hemoglobin A; insulin
Abbreviations: HbA1c, hemoglobin A1c; MET, ratio of work metabolic rate to resting metabolic rate; NHANES III, Third National Health and Nutrition Examination Survey
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Chao and J. H. Page Type 2 Diabetes Mellitus and Risk of Non-Hodgkin Lymphoma: A Systematic Review and Meta-Analysis Am. J. Epidemiol., September 1, 2008; 168(5): 471 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kim, Y. J. Cheng, and G. L. Beckles Inflammation Among Women With a History of Gestational Diabetes Mellitus and Diagnosed Diabetes in the Third National Health and Nutrition Examination Survey Diabetes Care, July 1, 2008; 31(7): 1386 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Petersen, A. L. Marsland, J. Flory, E. Votruba-Drzal, M. F. Muldoon, and S. B. Manuck Community Socioeconomic Status is Associated With Circulating Interleukin-6 and C-Reactive Protein Psychosom Med, July 1, 2008; 70(6): 646 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tzoulaki, M.-R. Jarvelin, A.-L. Hartikainen, M. Leinonen, A. Pouta, M. Paldanius, A. Ruokonen, D. Canoy, U. Sovio, P. Saikku, et al. Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 birth cohort study Eur. Heart J., April 9, 2008; (2008) ehn105v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Porrini, M. D. Gomez, A. Alvarez, M. Cobo, J. M. Gonzalez-Posada, L. Perez, L. Hortal, J. J. Garcia, M. Dolores Checa, A. Morales, et al. Glycated haemoglobin levels are related to chronic subclinical inflammation in renal transplant recipients without pre-existing or new onset diabetes Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1994 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Selvin, N. P. Paynter, and T. P. Erlinger The Effect of Weight Loss on C-Reactive Protein: A Systematic Review Arch Intern Med, January 8, 2007; 167(1): 31 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Albert, R. J. Glynn, J. Buring, and P. M Ridker Impact of Traditional and Novel Risk Factors on the Relationship Between Socioeconomic Status and Incident Cardiovascular Events Circulation, December 12, 2006; 114(24): 2619 - 2626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Loucks, L. M. Sullivan, L. J. Hayes, R. B. D'Agostino Sr., M. G. Larson, R. S. Vasan, E. J. Benjamin, and L. F. Berkman Association of Educational Level with Inflammatory Markers in the Framingham Offspring Study Am. J. Epidemiol., April 1, 2006; 163(7): 622 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C E Wrede, R Buettner, L C Bollheimer, J Scholmerich, K-D Palitzsch, and C Hellerbrand Association between serum ferritin and the insulin resistance syndrome in a representative population Eur. J. Endocrinol., February 1, 2006; 154(2): 333 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Verhaeghe, R. van Bree, S. Lambin, and S. Caluwaerts Adipokine Profile and C-Reactive Protein in Pregnancy: Effects of Glucose Challenge Response Versus Body Mass Index Reproductive Sciences, July 1, 2005; 12(5): 330 - 334. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Schaumberg, R. J. Glynn, A. J. Jenkins, T. J. Lyons, N. Rifai, J. E. Manson, P. M. Ridker, and D. M. Nathan Effect of Intensive Glycemic Control on Levels of Markers of Inflammation in Type 1 Diabetes Mellitus in the Diabetes Control and Complications Trial Circulation, May 17, 2005; 111(19): 2446 - 2453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Gustavsson and C.-D. Agardh Markers of inflammation in patients with coronary artery disease are also associated with glycosylated haemoglobin A1c within the normal range Eur. Heart J., December 1, 2004; 25(23): 2120 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Schulze, E. B. Rimm, T. Li, N. Rifai, M. J. Stampfer, and F. B. Hu C-Reactive Protein and Incident Cardiovascular Events Among Men With Diabetes Diabetes Care, April 1, 2004; 27(4): 889 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sajadieh, O. W. Nielsen, V. Rasmussen, H. O. Hein, S. Abedini, and J. F. Hansen Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease Eur. Heart J., March 1, 2004; 25(5): 363 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. King, A. G. Mainous III, T. A. Buchanan, and W. S. Pearson C-Reactive Protein and Glycemic Control in Adults With Diabetes: Response to Bell, Hardy, and Desmond Diabetes Care, February 1, 2004; 27(2): 637 - 638. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chandalia, A. V. Cabo-Chan Jr, S. Devaraj, I. Jialal, S. M. Grundy, and N. Abate Elevated Plasma High-Sensitivity C-Reactive Protein Concentrations in Asian Indians Living in the United States J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3773 - 3776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Kroenke, N.-F. Chu, N. Rifai, D. Spiegelman, S. E. Hankinson, J. E. Manson, and E. B. Rimm A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women Diabetes Care, July 1, 2003; 26(7): 1971 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Schram, N. Chaturvedi, C. Schalkwijk, F. Giorgino, P. Ebeling, J. H. Fuller, and C. D. Stehouwer Vascular Risk Factors and Markers of Endothelial Function as Determinants of Inflammatory Markers in Type 1 Diabetes: The EURODIAB Prospective Complications Study Diabetes Care, July 1, 2003; 26(7): 2165 - 2173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. King, A. G. Mainous III, T. A. Buchanan, and W. S. Pearson C-Reactive Protein and Glycemic Control in Adults With Diabetes Diabetes Care, May 1, 2003; 26(5): 1535 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Sekine, Y. Nishio, K. Egawa, T. Nakamura, H. Maegawa, and A. Kashiwagi Insulin Activates CCAAT/Enhancer Binding Proteins and Proinflammatory Gene Expression through the Phosphatidylinositol 3-Kinase Pathway in Vascular Smooth Muscle Cells J. Biol. Chem., September 20, 2002; 277(39): 36631 - 36639. [Abstract] [Full Text] [PDF]
|
|