American Journal of Epidemiology Vol. 155, No. 1 : 57-64
Copyright © 2002 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Leukocyte Count, Erythrocyte Sedimentation Rate, and Diabetes Incidence in a National Sample of US Adults
From the Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop K24, Atlanta, GA 30341 (e-mail: esf2{at}cdc.gov).
Emerging data suggest that inflammation may play a role in the etiology of diabetes mellitus. Because few prospective studies have addressed this issue, the author examined the relation between leukocyte count and erythrocyte sedimentation rate and diabetes incidence using data from the National Health and Nutrition Examination Survey Epidemiologic Follow-up Study (from 1971–1975 to 1992–1993). Of 8,352 participants included in the analysis, 878 developed incident diabetes during the approximately 20-year follow-up. After adjustment for age, smoking status, systolic blood pressure, cholesterol concentration, use of antihypertensive medication, recreational exercise, nonrecreational activity, alcohol use, and body mass index, the hazard ratios from proportional hazards for participants with a leukocyte count of 
9.1 x 109/liter compared with participants with a leukocyte count of 
5.7 x 109/liter were 1.33 (95% confidence interval (CI): 0.81, 2.19) for men and 1.68 (95% CI: 1.21, 2.34) for women. The adjusted hazard ratios for participants with an erythrocyte sedimentation rate of 26 mm/hour compared with participants with an erythrocyte sedimentation rate of 5 mm/hour were 1.85 (95% CI: 0.97, 3.54) for men and 0.83 (95% CI: 0.47, 1.44) for women. These results provide limited support to the hypothesis that inflammation is an etiologic factor for diabetes.
blood sedimentation; cohort studies; diabetes mellitus; incidence; inflammation; leukocytes
Abbreviations: CI, confidence interval; ICD-9 International Classification of Diseases, Ninth Revision; NHANES, National Health and Nutrition Examination Survey; NHEFS, National Health and Nutrition Examination Survey Epidemiologic Follow-up Study
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