American Journal of Epidemiology Vol. 154, No. 8 : 748-757
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Alcohol Consumption and the Risk of Type 2 Diabetes Mellitus: Atherosclerosis Risk in Communities Study
1 Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
2 Department of Medicine, University of Western Australia, Perth, Australia.
3 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN.
4 Division of Epidemiology, University of Mississippi Medical Center, Jackson, MS.
5 Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD.
Evidence regarding the association between alcohol consumption and type 2 diabetes risk remains inconsistent, particularly with regard to male-female differences. The authors conducted a prospective study of type 2 diabetes risk associated with alcohol consumption in a cohort of 12,261 middle-aged participants of the Atherosclerosis Risk in Communities Study (1990–1998), who were followed between 3 and 6 years. Alcohol consumption at baseline was characterized into lifetime abstainers, former drinkers, and current drinkers of various levels. Incident diabetes was determined by blood glucose measurements and self-report. After adjustment for potential confounders, an increased risk of diabetes was found in men who drank >21 drinks/week when compared with men who drank 
1 drink/week (odds ratio = 1.50, 95% confidence interval: 1.02, 2.20) while no significant association was found in women. This increased diabetes risk among men who drank >21 drinks/week was predominantly related to spirits rather than to beer or wine consumption. The relative odds of incident diabetes in a comparison of men who drank >14 drinks of spirits per week with men who were current drinkers but reported no regular use of spirits, beer, or wine were 1.82 (95% confidence interval: 1.14, 2.92). Results of this study support the hypothesis that high alcohol intake increases diabetes risk among middle-aged men. However, more moderate levels of alcohol consumption do not increase risk of type 2 diabetes in either middle-aged men or women.
alcohol drinking; cohort studies; diabetes mellitus; non-insulin-dependent; prospective studies
Abbreviations: ARIC, Atherosclerosis Risk in Communities
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