American Journal of Epidemiology Vol. 154, No. 7 : 624-634
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Low-to-Moderate Alcohol Consumption and Breast Cancer Risk by Age 50 Years among Women in Germany
1 Department of Clinical Epidemiology, Deutsches Krebs-forschungszentrum, Heidelberg, Germany.
2 Department of Tropical Hygiene and Public Health, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
Studies of the association between alcohol drinking and breast cancer show a tendency towards an increase in risk for high consumption levels but yield less consistent results for low-to-moderate levels, particularly among premenopausal women. In a population-based case-control study in Germany, the authors determined the effect of alcohol consumption at low-to-moderate levels on breast cancer risk among women up to age 50 years. The study included 706 case women whose breast cancer had been newly diagnosed in 1992–1995 and 1,381 residence- and age-matched controls. In multivariate conditional logistic regression analysis, the adjusted odds ratios for breast cancer were 0.71 (95% confidence interval (CI): 0.54, 0.91) for average ethanol intake of 1–5 g/day, 0.67 (95% CI: 0.50, 0.91) for intake of 6–11 g/day, 0.73 (95% CI: 0.51, 1.05) for 12–18 g/day, 1.10 (95% CI: 0.73, 1.65) for 19–30 g/day, and 1.94 (95% CI: 1.18, 3.20) for 
31 g/day. The association with high daily ethanol intake of 19 g was modified by educational level, such that odds ratios were 3.7, 1.6, and 0.7 for women with low, moderate, and high levels of education, respectively. These data suggest that low-level consumption of alcohol does not increase breast cancer risk in premenopausal women.
alcohol drinking; breast neoplasms; case-control studies; premenopause; wine
Abbreviations: CI, confidence interval; EPIC, European Prospective Investigation in Cancer
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