Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (102)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Peters, U.
Right arrow Articles by Arab, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peters, U.
Right arrow Articles by Arab, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 154, No. 6 : 495-503
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health

ORIGINAL CONTRIBUTIONS

Does Tea Affect Cardiovascular Disease? A Meta-Analysis

Ulrike Peters1,2, Charles Poole1 and Lenore Arab1

1 Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC.
2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

This meta-analysis of tea consumption in relation to stroke, myocardial infarction, and all coronary heart disease is based on 10 cohort studies and seven case-control studies. The study-specific effect estimates for stroke and coronary heart disease were too heterogeneous to be summarized (homogeneity p < 0.02 for stroke, p < 0.001 for coronary heart disease). Only the relative risk estimates for myocardial infarction (seven studies) appeared reasonably homogeneous (homogeneity p = 0.20). The incidence rate of myocardial infarction is estimated to decrease by 11% with an increase in tea consumption of 3 cups per day (fixed-effects relative risk estimate = 0.89, 95% confidence interval: 0.79, 1.01) (1 cup = 237 ml). However, evidence of bias toward preferential publication of smaller studies that suggest protective effects urges caution in interpreting this result. The geographic region where the studies were conducted appeared to explain much of the heterogeneity among coronary heart disease, myocardial infarction, and probably stroke results. With increasing tea consumption, the risk increased for coronary heart disease in the United Kingdom and for stroke in Australia, whereas the risk decreased in other regions, particularly in continental Europe.

cardiovascular diseases; cerebrovascular accident; coronary disease; meta-analysis; myocardial infarction; tea


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Psychosom. Med.Home page
J. Corley, X. Jia, J. A. M. Kyle, A. J. Gow, C. E. Brett, J. M. Starr, G. McNeill, and I. J. Deary
Caffeine Consumption and Cognitive Function at Age 70: The Lothian Birth Cohort 1936 Study
Psychosom Med, February 1, 2010; 72(2): 206 - 214.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. Arab, W. Liu, and D. Elashoff
Green and Black Tea Consumption and Risk of Stroke: A Meta-Analysis
Stroke, May 1, 2009; 40(5): 1786 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. Arab and J. B. Blumberg
Proceedings of the Fourth International Scientific Symposium on Tea and Human Health. September 18, 2007. Washington, DC, USA.
J. Nutr., August 1, 2008; 138(8): 1526S - 1588S.
[Full Text] [PDF]

Home page
 J. Nutr.Home page
D. Grassi, A. Aggio, L. Onori, G. Croce, S. Tiberti, C. Ferri, L. Ferri, and G. Desideri
Tea, Flavonoids, and Nitric Oxide-Mediated Vascular Reactivity
J. Nutr., August 1, 2008; 138(8): 1554S - 1560S.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
I. C. W. Arts
A Review of the Epidemiological Evidence on Tea, Flavonoids, and Lung Cancer
J. Nutr., August 1, 2008; 138(8): 1561S - 1566S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Angeloni, E. Leoncini, M. Malaguti, S. Angelini, P. Hrelia, and S. Hrelia
Role of quercetin in modulating rat cardiomyocyte gene expression profile
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1233 - H1243.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
J. O. Clarke and G. E. Mullin
A Review of Complementary and Alternative Approaches to Immunomodulation
Nutr Clin Pract, February 1, 2008; 23(1): 49 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. Debette, D. Courbon, N. Leone, J. Gariepy, C. Tzourio, J.-F. Dartigues, P. Barberger-Gateau, K. Ritchie, A. Alperovitch, P. Amouyel, et al.
Tea Consumption Is Inversely Associated With Carotid Plaques in Women
Arterioscler Thromb Vasc Biol, February 1, 2008; 28(2): 353 - 359.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
S. M. Shenouda and J. A. Vita
Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function
J. Am. Coll. Nutr., August 1, 2007; 26(4): 366S - 372S.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. Lin, K. M. Rexrode, F. Hu, C. M. Albert, C. U. Chae, E. B. Rimm, M. J. Stampfer, and J. E. Manson
Dietary Intakes of Flavonols and Flavones and Coronary Heart Disease in US Women
Am. J. Epidemiol., June 1, 2007; 165(11): 1305 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
D. Taubert, R. Roesen, and E. Schomig
Effect of Cocoa and Tea Intake on Blood Pressure: A Meta-analysis
Arch Intern Med, April 9, 2007; 167(7): 626 - 634.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
M. E. Widlansky, N. M. Hamburg, E. Anter, M. Holbrook, D. F. Kahn, J. G. Elliott, J. F. Keaney Jr., and J. A. Vita
Acute EGCG Supplementation Reverses Endothelial Dysfunction in Patients with Coronary Artery Disease
J. Am. Coll. Nutr., April 1, 2007; 26(2): 95 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. W. Erdman Jr., D. Balentine, L. Arab, G. Beecher, J. T. Dwyer, J. Folts, J. Harnly, P. Hollman, C. L. Keen, G. Mazza, et al.
Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC
J. Nutr., March 1, 2007; 137(3): 718S - 737S.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
H. Yamada and H. Watanabe
Tea polyphenols in preventing cardiovascular diseases
Cardiovasc Res, January 15, 2007; 73(2): 439 - 440.
[Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
K. J. Mukamal, M. Alert, M. Maclure, J. E. Muller, and M. A. Mittleman
Tea Consumption and Infarct-Related Ventricular Arrhythmias: The Determinants of Myocardial Infarction Onset Study
J. Am. Coll. Nutr., December 1, 2006; 25(6): 472 - 479.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
C. Cabrera, R. Artacho, and R. Gimenez
Beneficial effects of green tea--a review.
J. Am. Coll. Nutr., April 1, 2006; 25(2): 79 - 99.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
B. M Popkin, L. E Armstrong, G. M Bray, B. Caballero, B. Frei, and W. C Willett
A new proposed guidance system for beverage consumption in the United States
Am. J. Clinical Nutrition, March 1, 2006; 83(3): 529 - 542.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
S. Tokudome, I. Nahomi, C. Goto, Y. Tokudome, and M. A Moore
Black tea and cardiovascular disease
Int. J. Epidemiol., April 1, 2005; 34(2): 482 - 483.
[Full Text] [PDF]

Home page
 Int J EpidemiolHome page
C. Poole, U. Peters, D. Il'yasova, and L. Arab
Authors' response
Int. J. Epidemiol., April 1, 2005; 34(2): 483 - 483.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. A Vita
Polyphenols and cardiovascular disease: effects on endothelial and platelet function
Am. J. Clinical Nutrition, January 1, 2005; 81(1): 292S - 297S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
I. C. Arts and P. C. Hollman
Polyphenols and disease risk in epidemiologic studies
Am. J. Clinical Nutrition, January 1, 2005; 81(1): 317S - 325S.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
Y.-C. Yang, F.-H. Lu, J.-S. Wu, C.-H. Wu, and C.-J. Chang
The Protective Effect of Habitual Tea Consumption on Hypertension
Arch Intern Med, July 26, 2004; 164(14): 1534 - 1540.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
K. W. Lee and G. Y. H. Lip
Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity: A Systematic Review
Arch Intern Med, October 27, 2003; 163(19): 2368 - 2392.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. Rietveld and S. Wiseman
Antioxidant Effects of Tea: Evidence from Human Clinical Trials
J. Nutr., October 1, 2003; 133(10): 3285S - 3292.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. M Hodgson, A. Devine, I. B. Puddey, S. Y. Chan, L. J. Beilin, and R. L. Prince
Tea Intake Is Inversely Related to Blood Pressure in Older Women
J. Nutr., September 1, 2003; 133(9): 2883 - 2886.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
H. D Sesso, R. S Paffenbarger Jr, Y. Oguma, and I-M. Lee
Lack of association between tea and cardiovascular disease in college alumni
Int. J. Epidemiol., August 1, 2003; 32(4): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
C. Poole, U. Peters, D. Il'yasova, and L. Arab
Commentary: This study failed?
Int. J. Epidemiol., August 1, 2003; 32(4): 534 - 535.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
D. J. Maron, G. P. Lu, N. S. Cai, Z. G. Wu, Y. H. Li, H. Chen, J. Q. Zhu, X. J. Jin, B. C. Wouters, and J. Zhao
Cholesterol-Lowering Effect of a Theaflavin-Enriched Green Tea Extract: A Randomized Controlled Trial
Arch Intern Med, June 23, 2003; 163(12): 1448 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. M Hodgson, V. Burke, L. J Beilin, K. D Croft, and I. B Puddey
Can black tea influence plasma total homocysteine concentrations?
Am. J. Clinical Nutrition, April 1, 2003; 77(4): 907 - 911.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
A. G. Thrift and G. A. Donnan
RE: "DOES TEA AFFECT CARDIOVASCULAR DISEASE? A META-ANALYSIS"
Am. J. Epidemiol., September 1, 2002; 156(5): 490 - 490.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
U. Peters, C. Poole, and L. Arab
THE AUTHORS REPLY
Am. J. Epidemiol., September 1, 2002; 156(5): 490 - 491.
[Full Text] [PDF]

Home page
 Am J EpidemiolHome page
RE: "DOES TEA AFFECT CARDIOVASCULAR DISEASE? A META-ANALYSIS"
Am. J. Epidemiol., April 15, 2002; 155(8): 781 - 781.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.