Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Klipstein-Grobusch, K.
Right arrow Articles by Witteman, J. C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klipstein-Grobusch, K.
Right arrow Articles by Witteman, J. C. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 154, No. 2 : 145-149
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health

ORIGINAL CONTRIBUTIONS

Dietary Antioxidants and Peripheral Arterial Disease

The Rotterdam Study

Kerstin Klipstein-Grobusch1,2, Johanna H. den Breeijen3, Diederick E. Grobbee3, Heiner Boeing2, Albert Hofman1 and Jacqueline C. M. Witteman1

1 Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, the Netherlands.
2 Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
3 Julius Center for Patient Oriented Research, Utrecht University Hospital, Utrecht, the Netherlands.

This study examined cross-sectionally the association of dietary ß-carotene, vitamin C, and vitamin E with peripheral arterial disease in Rotterdam, the Netherlands (1990–1993). The 4,367 subjects from the Rotterdam Study were aged 55–94 years and had no previous cardiovascular disease at baseline. Diet was assessed with a food frequency questionnaire. Peripheral arterial disease was defined as an ankle-arm systolic blood pressure index (AAI) of <=0.9 and was present in 204 men and 370 women. In multivariate-adjusted logistic regression analyses, vitamin C intake was significantly inversely associated with peripheral arterial disease in women (highest vs. lowest quartile: relative risk = 0.64, 95% confidence interval (CI): 0.48, 0.89; ptrend = 0.006), and a 100-mg increase in intake was associated with a 0.013 AAI increase (95% CI: 0.001, 0.025). In men, vitamin E intake was inversely associated with peripheral arterial disease (relative risk = 0.67, 95% CI: 0.44, 1.03; ptrend = 0.067); a 10-mg increase in intake was associated with a 0.015 AAI increase (95% CI: 0.001, 0.031). Whether these differences in antioxidant intake and the risk of a low AAI and of peripheral arterial disease between sexes are attributable to a different food pattern for men compared with women remains to be elucidated.

antioxidants; arterial occlusive diseases; ascorbic acid; beta carotene; cardiovascular diseases; cross-sectional studies; diet; vitamin E

Abbreviations: AAI, ankle-arm systolic blood pressure index; CI, confidence interval


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J CARDIOVASC PHARMACOL THERHome page
R. Siekmeier, C. Steffen, and W. Marz
Role of Oxidants and Antioxidants in Atherosclerosis: Results of In Vitro and In Vivo Investigations
Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2007; 12(4): 265 - 282.
[Abstract] [PDF]

Home page
 J. Lipid Res.Home page
P. M. Clifton, M. Noakes, D. Ross, A. Fassoulakis, M. Cehun, and P. Nestel
High dietary intake of phytosterol esters decreases carotenoids and increases plasma plant sterol levels with no additional cholesterol lowering
J. Lipid Res., August 1, 2004; 45(8): 1493 - 1499.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. H. Dwyer, M. J. Paul-Labrador, J. Fan, A. M. Shircore, C. N. B. Merz, and K. M. Dwyer
Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study
Arterioscler. Thromb. Vasc. Biol., February 1, 2004; 24(2): 313 - 319.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.