American Journal of Epidemiology Vol. 154, No. 1 : 50-59
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Relation of Sleep-disordered Breathing to Cardiovascular Disease Risk Factors
The Sleep Heart Health Study
University of Pittsburgh, Pittsburgh, PA.
The Johns Hopkins University, Baltimore, MD.
Boston University, Boston, MA.
University of Washington, Seattle, WA.
Cleveland Rainbow Babies' and Children's Hospital, Cleveland, OH.
University of Minnesota, Minneapolis, MN.
Cornell University, New York, NY.
University of Arizona, Tucson, AZ.
Associations between sleep-disordered breathing and cardiovascular disease (CVD) may be mediated by higher cardiovascular risk factor levels in those with sleep-disordered breathing. The authors examined these relations in the Sleep Heart Health Study, a multiethnic cohort of 6,440 men and women over age 40 years conducted from October 1995 to February 1998 and characterized by home polysomnography. In 4,991 participants who were free of self-reported CVD at the time of the sleep study, moderate levels of sleep-disordered breathing were common, with a median Respiratory Disturbance Index (RDI) of 4.0 (interquartile range, 1.25–10.7). The level of RDI was associated cross-sectionally with age, body mass index, waist-to-hip ratio, hypertension, diabetes, and lipid levels. These relations were more pronounced in those under age 65 years than in those over age 65. Women under age 65 years with RDI in the higher quartiles were more obese than men with similar RDI. Although the pattern of associations was consistent with greater obesity in those with higher RDI, higher body mass index did not explain all of these associations. If sleep-disordered breathing is shown in future follow-up to increase the risk for incident CVD events, part of the risk is likely to be due to the higher cardiovascular risk factors in those with higher RDI.
cardiovascular diseases; respiration; sleep apnea syndromes; sleep disorders
Abbreviations: BMI, body mass index; CVD, cardiovascular disease; HDL, high density lipoprotein; RDI, Respiratory Disturbance Index; SHHS, Sleep Heart Health Study
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