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American Journal of Epidemiology Vol. 153, No. 8 : 794-798
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health

ORIGINAL CONTRIBUTIONS

Association between HLA-DQB1 Alleles and Type 1 Diabetes in a Case-Parents Study Conducted in Santiago, Chile

J. L. Santos1, F. Pérez-Bravo1, E. Carrasco2, M. Calvillán2 and C. Albala1

1 Department of Epidemiology, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
2 Division of Diabetes, San Juan de Dios Hospital, Faculty of Medicine, University of Chile, Santiago, Chile.

The human leukocyte antigen (HLA) system plays a crucial role in the autoimmune process leading to childhood diabetes. The purpose of this study was to evaluate the association between type 1 diabetes and the polymorphism encoded by the HLA-DQB1 gene by using case-parents trios. The study area was the metropolitan region of Santiago, Chile, and cases were ascertained from March 1997 to August 1998. Genotyping was performed in 94 trios comprising incident cases less than 17 years of age at the time of diagnosis and their parents. The transmission/disequilibrium test was used to detect differential transmission in the HLA-DQB1 locus. The authors found that alleles DQB1*0302 and DQB1*0201 were strongly associated with the disease. By using 1:3 matched sets of cases-pseudosibs and conditional logistic regression models, allelic relative risks were estimated for DQB1*0302 (r = 7.2, 95% confidence interval: 2.8, 18.5) and DQB1*0201 (r = 4.7, 95% confidence interval: 1.9, 11.6); DQB1*0301 was considered the baseline allele. When case-parents trios were used, alleles DQB1*0302 and DQB1*0201 were strongly associated with a higher risk of type 1 diabetes in the population of Santiago.

alleles; association; case-control studies; diabetes mellitus, insulin-dependent; genetics; HLA antigens; parents

Abbreviations: HLA, human leukocyte antigen; TDT, transmission/disequilibrium test.


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