American Journal of Epidemiology Vol. 153, No. 8 : 740-748
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Human Papillomaviruses and Cervical Cancer in Bangkok. III. The Role of Husbands and Commercial Sex Workers
1 Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA.
2 Department of Pathology, University of Washington, Seattle, WA.
3 Faculty of Medicine, Mahidol University, Department of Obstetrics and Gynecology, Siriraj Hospital, and Siriraj Family Planning Research Center, Bangkok, Thailand.
4 Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA.
Between September 1991 and September 1993, husbands of women with and without cervical neoplasia and commercial sex workers in one brothel and one massage parlor in Bangkok, Thailand, were interviewed; serologic tests for sexually transmitted infections were performed; and cervical and penile scrapings were tested for human papillomavirus (HPV) DNA. The risks of cervical carcinoma in monogamous women and of oncogenic HPV in their husbands were associated with the men's having unprotected intercourse with prostitutes. The prevalence of oncogenic HPV was higher in commercial sex workers than in women attending gynecologic and family planning clinics. Oncogenic HPV prevalence declined with age in human immunodeficiency virus (HIV)-negative, but not in healthy HIV-positive, commercial sex workers and was weakly associated with hepatitis B antigenemia, suggesting that persistence of HPV infection is due to subtle changes in immunity. Associations of HPV with recent pregnancy and oral contraceptive use suggest that hormonal factors may increase the risk of cervical neoplasia by enhancing persistence of HPV infection. The prevalence of high-grade squamous intraepithelial lesions was strongly related to oncogenic HPV types and weakly to HIV infection only in their presence. Commercial sex workers in Bangkok are reservoirs of oncogenic HPV, and cervical cancer in monogamous Thai women develops in part as a result of transmission of these viruses to them by their husbands from prostitutes.
cervix neoplasms; papillomavirus, human; prostitution; sexual partners
Abbreviations: DMPA, depot-medroxyprogesterone acetate; HBsAg, hepatitis B surface antigen; HGSIL, high-grade squamous intraepithelial lesions; HIV, human immunodeficiency virus; HPV, human papillomavirus.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M O Ng'ayo, E Bukusi, A Rowhani-Rahbar, L A Koutsky, Q Feng, Z A Kwena, and K K Holmes Epidemiology of human papillomavirus infection among fishermen along Lake Victoria Shore in the Kisumu District, Kenya Sex Transm Inf, February 1, 2008; 84(1): 62 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T M Groom and R Nandwani Characteristics of men who pay for sex: a UK sexual health clinic survey. Sex Transm Inf, October 1, 2006; 82(5): 364 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Wee, M E Barrett, W M Lian, T Jayabaskar, and K W R Chan Determinants of inconsistent condom use with female sex workers among men attending the STD clinic in Singapore Sex Transm Inf, August 1, 2004; 80(4): 310 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F X Bosch, A Lorincz, N Munoz, C J L M Meijer, and K V Shah The causal relation between human papillomavirus and cervical cancer J. Clin. Pathol., April 1, 2002; 55(4): 244 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Thomas, R. M. Ray, A. Koetsawang, N. Kiviat, J. Kuypers, Q. Qin, R. L. Ashley, and S. Koetsawang Human Papillomaviruses and Cervical Cancer in Bangkok. I. Risk Factors for Invasive Cervical Carcinomas with Human Papillomavirus Types 16 and 18 DNA Am. J. Epidemiol., April 15, 2001; 153(8): 723 - 731. [Abstract] [Full Text] [PDF]
|
|