American Journal of Epidemiology Vol. 153, No. 7 : 666-672
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Incidence of and Risk Factors for Asymptomatic Peripheral Arterial Occlusive Disease: A Longitudinal Study
1 Department of General Practice, Research Institute for Extramural and Transmural Health Care, Maastricht University, Maastricht, The Netherlands.
2 Department of Methodology and Statistics, Research Institute for Extramural and Transmural Health Care, Maastricht University, Maastricht, The Netherlands.
The current study describes the age- and sex-specific incidence rates and risk factors for asymptomatic and symptomatic peripheral arterial occlusive disease (PAOD) among 2,327 subjects and the incidence of intermittent claudication in asymptomatic PAOD subjects. The study population was selected from 18 general practice centers in the Netherlands. PAOD was assessed with the ankle-brachial blood pressure index, and intermittent claudication was assessed with a modified version of the Rose questionnaire. After 7.2 years, the overall incidence rate for asymptomatic PAOD, using the person-years method, was 9.9 (95% confidence interval (CI): 7.3, 18.8) per 1,000 person-years at risk. The rate was 7.8 (95% CI: 4.9, 20.3) for men and 12.4 (95% CI: 7.7, 24.8) for women. For symptomatic PAOD, the incidence rate was 1.0 (95% CI: 0.7, 7.5) overall, 0.4 (95% CI: 0.3, 10.0) for men, and 1.8 (95% CI: 1.0, 10.3) for women. Multivariate analyses showed that increasing age, smoking, hypertension, and diabetes mellitus were the most important risk factors. The overall incidence rate for intermittent claudication among PAOD subjects who were asymptomatic at baseline was 90.5 per 1,000 person-years at risk (95% CI: 36.4, 378.3). The incidence of asymptomatic PAOD was higher than the incidence of symptomatic PAOD, with women developing PAOD more often than men. In the development of preventive strategies, modification of atherosclerotic risk factors, such as smoking, hypertension, and diabetes, should be the main goals.
arterial occlusive diseases; incidence; intermittent claudication; longitudinal studies; risk factors
Abbreviations: OR, odds ratio; PAOD, peripheral arterial occlusive disease.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. D. Pradhan, S. Shrivastava, N. R. Cook, N. Rifai, M. A. Creager, and P. M Ridker Symptomatic Peripheral Arterial Disease in Women: Nontraditional Biomarkers of Elevated Risk Circulation, February 12, 2008; 117(6): 823 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sritara, C. Sritara, M. Woodward, S. Wangsuphachart, F. Barzi, B. Hengprasith, and T. Yipintsoi Prevalence and Risk Factors of Peripheral Arterial Disease in a Selected Thai Population Angiology, November 1, 2007; 58(5): 572 - 578. [Abstract] [PDF]
|
|
|
|
 |
|
 R. V. Milani and C. J. Lavie The role of exercise training in peripheral arterial disease Vascular Medicine, November 1, 2007; 12(4): 351 - 358. [Abstract] [PDF]
|
|
|
|
 |
|
 C. A. Stueckle, L. Claeys, K. Haegele, S. Zimmermann, S. Mruck, S. Adams, and D. Liermann Diagnostic value of proton MR spectroscopy in peripheral arterial occlusive disease: a prospective evaluation. Am. J. Roentgenol., November 1, 2006; 187(5): 1322 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Diehm, S. Lange, H. Darius, D. Pittrow, B. von Stritzky, G. Tepohl, R. L. Haberl, J. R. Allenberg, B. Dasch, H. J. Trampisch, et al. Association of low ankle brachial index with high mortality in primary care Eur. Heart J., July 2, 2006; 27(14): 1743 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Hirsch, Z. J. Haskal, N. R. Hertzer, C. W. Bakal, M. A. Creager, J. L. Halperin, L. F. Hiratzka, W. R.C. Murphy, J. W. Olin, J. B. Puschett, et al. ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): Executive Summary A Collaborative Report From the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1239 - 1312. [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Hankey, P. E. Norman, and J. W. Eikelboom Medical Treatment of Peripheral Arterial Disease JAMA, February 1, 2006; 295(5): 547 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Eason, N. J. Petersen, M. Suarez-Almazor, B. Davis, and T. C. Collins Diabetes Mellitus, Smoking, and the Risk for Asymptomatic Peripheral Arterial Disease: Whom Should We Screen? J Am Board Fam Med, September 1, 2005; 18(5): 355 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Leibson, J. E. Ransom, W. Olson, B. R. Zimmerman, W. M. O'Fallon, and P. J. Palumbo Peripheral Arterial Disease, Diabetes, and Mortality Diabetes Care, December 1, 2004; 27(12): 2843 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kroger Dyslipoproteinemia and Peripheral Arterial Occlusive Disease Angiology, March 1, 2004; 55(2): 135 - 138. [Abstract] [PDF]
|
|
|
|
|
|
L. V. Buitron-Granados, C. Martinez-Lopez, and J. Escobedo-de la Pena Prevalence of Peripheral Arterial Disease and Related Risk Factors in an Urban Mexican Population Angiology, January 1, 2004; 55(1): 43 - 51. [Abstract] [PDF]
|
|