American Journal of Epidemiology Vol. 153, No. 5 : 506-514
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Multivariate Logistic Regression for Familial Aggregation of Two Disorders. II. Analysis of Studies of Eating and Mood Disorders
1 Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA.
2 Department of Psychiatry, Harvard Medical School, Boston, MA.
3 Department of Biostatistics, Harvard School of Public Health, Boston, MA.
4 Department of Epidemiology, Harvard School of Public Health, Boston, MA.
5 Biological Psychiatry Program and Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH.
Family studies have suggested that eating disorders and mood disorders may coaggregate within families. Previous studies, however, have been limited by use of univariate modeling techniques and failure to account for the correlation of observations within families. To provide a more efficient analysis and to illustrate multivariate logistic regression models for familial aggregation of two disorders, the authors analyzed pooled data from two previously published family studies (conducted in Massachusetts in 1984–1986 and 1986–1987) by using multivariate proband predictive and family predictive models. Both models demonstrated a significant familial aggregation of mood disorders and familial coaggregation of eating and mood disorders. The magnitude of the coaggregation between eating and mood disorders was similar to that of the aggregation of mood disorders. Similar results were obtained with alternative models, including a traditional univariate proband predictive model. In comparison with the univariate model, the multivariate models provided greater flexibility, improved precision, and wider generality for interpreting aggregation effects.
anorexia nervosa; bulimia; depressive disorder; eating disorders; family characteristics; logistic models; mood disorders
Abbreviations: ED alone-both, coaggregation of eating disorders alone and both disorders; ED alone-ED alone, aggregation of eating disorders alone within families; ED alone-MD alone, coaggregation of eating disorders alone and mood disorders alone within different family members; ED-ED, aggregation of eating disorders within families; ED-MD, coaggregation of eating and mood disorders within different family members; GEE, generalized estimating equations; MD alone-both, coaggregation of mood disorders alone and both disorders; MD alone-MD alone, aggregation of mood disorders alone within families; MD-MD, aggregation of mood disorders within families.
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