American Journal of Epidemiology Vol. 153, No. 3 : 242-250
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population
1 Department of Pathology, College of Medicine, University of Vermont, Burlington, VT.
2 Department of Medicine, College of Medicine, University of Vermont, Burlington, VT.
3 Department of Public Health Sciences, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.
4 Department of Radiology, Harvard Medical School, Boston, MA.
5 Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT.
Higher levels of physical activity are associated with lower risk of cardiovascular disease. There is growing evidence that the development of the atherosclerotic plaque is associated with inflammation. In this study, the authors investigated the cross-sectional association between physical activity and markers of inflammation in a healthy elderly population. Data obtained in 1989–1990 and 1992–1993 from the Cardiovascular Health Study, a cohort of 5,888 men and women aged 
65 years, were analyzed. Concentrations of the inflammation markers–C-reactive protein, fibrinogen, Factor VIII activity, white blood cells, and albumin–were compared cross-sectionally by quartile of self-reported physical activity. Compared with persons in the lowest quartile, those in the highest quartile of physical activity had 19%, 6%, 4%, and 3% lower concentrations of C-reactive protein, white blood cells, fibrinogen, and Factor VIII activity, respectively, after adjustment for gender, the presence of cardiovascular disease, age, race, smoking, body mass index, diabetes, and hypertension. Multivariate regression models suggested that the association of higher levels of physical activity with lower levels of inflammation markers may be mediated by body mass index and glucose. There was no association between physical activity and albumin. Higher levels of physical activity were associated with lower concentrations of four out of five inflammation markers in this elderly cohort. These data suggest that increased exercise is associated with reduced inflammation. Prospective studies will be required for verification of these findings.
atherosclerosis; cardiovascular diseases; C-reactive protein; exercise; Factor VIII; fibrinogen; inflammation; leukocyte count
Abbreviations: CHS, Cardiovascular Health Study; CV, coefficient of variation.
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