American Journal of Epidemiology Vol. 153, No. 3 : 207-214
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Immunity to Poliomyelitis in the Netherlands
1 Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, the Netherlands.
2 Laboratory for Control of Biological Products, National Institute of Public Health and the Environment, Bilthoven, the Netherlands.
3 Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, the Netherlands.
4 Department of Virology, Eijkman Winkler Institute, University Medical Center Utrecht, Utrecht, the Netherlands.
Despite a vaccination coverage rate of 97%, several poliomyelitis outbreaks occurred in the Netherlands during the last three decades, all among sociogeographically clustered, unvaccinated persons. Therefore, to eradicate polio, insight into poliomyelitis immunity is particularly useful. In 1995–1996, the authors conducted a population-based study and determined neutralizing antibodies against poliovirus types 1, 2, and 3 in 9,274 sera from the general population and from religious groups rejecting vaccination. In the general population, the antibody prevalence (
1:8) was 96.6% (95% confidence interval (CI): 95.9, 97.2), 93.4% (95% CI: 92.3, 94.5), and 89.7% (95% CI: 88.3, 91.0) for poliovirus types 1, 2, and 3, respectively. Antibodies persisted for long periods in persons with natural immunity as well as in persons whose immunity was induced by inactivated polio vaccine. In Orthodox Reformed persons, the antibody prevalence of poliovirus types 1, 2, and 3 was 65.0% (95% CI: 57.2, 72.9), 59.0% (95% CI: 40.1, 77.9), and 68.7% (95% CI: 65.2, 72.2), respectively. The recent outbreaks clearly affected the seroprevalence profiles of Orthodox Reformed groups but not the general population. At present, there is an insufficient social and political basis for mandatory vaccination; therefore, global eradication of poliovirus seems to be the only way to protect these Orthodox Reformed persons against future poliomyelitis outbreaks.
antibodies; immunity; poliomyelitis; polioviruses; seroepidemiologic studies; vaccination
Abbreviations: CI, confidence interval
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in Am. J. Epidemiol.:
- Invited Commentary: Stopping Polio Immunization
- Harry F. Hull, R. Bruce Aylward, and Julie Milstien
Am. J. Epidemiol. 2001 153: 215-216.[Extract] [FREE Full Text] - The Authors Respond to Hull et al.
- Tjeerd G. Kimman, Hester E. de Melker, Frithjofna Abbink, Nazrin Elzinga-Gholizadea, Ton van Loon, and Marina A. E. Conyn-van Spaendonck
Am. J. Epidemiol. 2001 153: 217-218.[Extract] [FREE Full Text]
This article has been cited by other articles:
|
|
 |
|
  S. Zurbriggen, K. Tobler, C. Abril, S. Diedrich, M. Ackermann, M. A. Pallansch, and A. Metzler Isolation of Sabin-Like Polioviruses from Wastewater in a Country Using Inactivated Polio Vaccine Appl. Envir. Microbiol., September 15, 2008; 74(18): 5608 - 5614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Duintjer Tebbens, M. A. Pallansch, O. M. Kew, V. M. Caceres, R. W. Sutter, and K. M. Thompson A Dynamic Model of Poliomyelitis Outbreaks: Learning from the Past to Help Inform the Future Am. J. Epidemiol., August 15, 2005; 162(4): 358 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 NVAC-ACIP Joint Working Group and Centers for Dise Ensuring Preparedness for Potential Poliomyelitis Outbreaks: Recommendations for the US Poliovirus Vaccine Stockpile From the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP) Arch Pediatr Adolesc Med, December 1, 2004; 158(12): 1106 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Smith, S. Y. Chu, and L. E. Barker Children Who Have Received No Vaccines: Who Are They and Where Do They Live? Pediatrics, July 1, 2004; 114(1): 187 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Arya, M. A. E. Conyn-van Spaendonck, H. E. de Melker, F. Abbink, N. Elzinga-Gholizadea, T. G. Kimman, and T. van Loon RE: "IMMUNITY TO POLIOMYELITIS IN THE NETHERLANDS" Am. J. Epidemiol., October 1, 2001; 154(7): 684 - 685. [Full Text] [PDF]
|
|
|
|
|
|
H. F. Hull, R. B. Aylward, and J. Milstien Invited Commentary: Stopping Polio Immunization Am. J. Epidemiol., February 1, 2001; 153(3): 215 - 216. [Full Text] [PDF]
|
|
|
|
|
|
T. G. Kimman, H. E. de Melker, F. Abbink, N. Elzinga-Gholizadea, T. v. Loon, and M. A. E. Conyn-van Spaendonck The Authors Respond to Hull et al. Am. J. Epidemiol., February 1, 2001; 153(3): 217 - 218. [Full Text] [PDF]
|
|