American Journal of Epidemiology, Vol 152, Issue 9 863-867, Copyright © 2000 by Oxford University Press
C Nagata, N Takatsuka, N Kawakami and H Shimizu
A prospective study was conducted in Takayama, Gifu, Japan, to evaluate the
association between diet and the onset of menopause. A total of 1,130
female residents aged 35-54 years who were premenopausal and completed a
validated semiquantitative food frequency questionnaire in 1992 were
contacted by mail with a follow-up questionnaire in 1998 to update
information on menopause. Onset of menopause was defined as a woman's age
at the last menstrual period prior to stopping menstruation for 12 months.
During the 6-year study period, 296 women experienced natural menopause.
The Cox proportional hazards model was used to estimate hazard ratios of
the onset of menopause after controlling for age, total energy, body mass
index, years of smoking, and age at which regular menstrual cycle began.
The authors found that green and yellow vegetable intake was significantly
inversely associated with the 6-year incidence of menopause (hazard ratio =
0.71, 95% confidence interval: 0.54, 0.95 for the highest vs. lowest
tertile of intake, p for trend = 0.02). Association of carotene intake with
the incidence of menopause was of borderline significance (hazard ratio =
0.78, 95% confidence interval: 0.59, 1.04, p for trend = 0.07).
Association of diet with the onset of menopause in Japanese women [In Process Citation]
Department of Public Health, Gifu University School of Medicine, Tsukasa-machi, Japan. chisato@cc.gifu-u.ac.jp
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