American Journal of Epidemiology, Vol 152, Issue 9 847-854, Copyright © 2000 by Oxford University Press
TK Murphy, EE Calle, C Rodriguez, HS Khan and MJ Thun
Obesity has been reported to increase the risk of colon cancer, especially
in men. The authors examined this relation in the American Cancer Society's
Cancer Prevention Study II, a nationwide mortality study of US adults.
After 12 years of follow-up, 1,616 deaths from colon cancer in women and
1,792 in men were observed among 496,239 women and 379,167 men who were
cancer free at enrollment in 1982. The authors used Cox proportional
hazards analyses to control for effects of age, race, education, smoking,
exercise, alcohol, parental history of colon cancer, fat intake, vegetable
and grain intake, aspirin use and, in women, estrogen replacement therapy.
In men, death rates from colon cancer increased across the entire range of
body mass index (BMI). The rate ratio was highest for men with BMI > or
=32.5 (rate ratio (RR) = 1.90, 95% confidence interval (CI): 1.46, 2.47)
compared with men with BMI between 22.00 and 23.49. In women, a weaker
association was seen in the three BMI categories of 27.5-29.9 (RR = 1.26,
95% CI: 1.03, 1.53), 30.0-32.4 (RR = 1.37, 95% CI: 1.09, 1.72), and > or
=32.5 (RR = 1.23, 95% CI: 0.96, 1.59). These prospective data support the
hypothesis that obesity increases the risk of colon cancer death and that
the relation is stronger and more linear in men than in women.
Body mass index and colon cancer mortality in a large prospective study [In Process Citation]
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329-4251, USA.
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