American Journal of Epidemiology, Vol 152, Issue 9 838-846, Copyright © 2000 by Oxford University Press
SE Carozza, M Wrensch, R Miike, B Newman, AF Olshan, DA Savitz, M Yost and M Lee
Lifetime job histories from a population-based, case-control study of
gliomas diagnosed among adults in the San Francisco Bay area between August
1991 and April 1994 were evaluated to assess occupational risk factors.
Occupational data for 476 cases and 462 controls were analyzed, with
adjustment for age, gender, education, and race. Imprecise increased risks
were observed for physicians and surgeons (odds ratio (OR) = 3.5, 95%
confidence interval (CI): 0.7, 17.6), artists (OR = 1.9, 95% CI: 0.5, 6.5),
foundry and smelter workers (OR = 2.6, 95% CI: 0.5, 13.1), petroleum and
gas workers (OR = 4.9, 95% CI: 0.6, 42.2), and painters (OR = 1.6, 95% CI:
0.5, 4.9). Legal and social service workers, shippers, janitors, motor
vehicle operators, and aircraft operators had increased odds ratios only
with longer duration of employment. Physicians and surgeons, foundry and
smelter workers, petroleum and gas workers, and painters showed increased
risk for both astrocytic and nonastrocytic tumors. Artists and firemen had
increased risk for astrocytic tumors only, while messengers, textile
workers, aircraft operators, and vehicle manufacturing workers showed
increased risk only for nonastrocytic tumors. Despite study limitations,
including small numbers for many of the occupational groups, a high
percentage of proxy respondents among cases, and lack of specific exposure
information, associations were observed for several occupations previously
reported to be at higher risk for brain tumors generally and gliomas
specifically.
Occupation and adult gliomas [In Process Citation]
Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M University System Health Science Center, College Station 77843-1266, USA. scarozza@medicine.tamu.edu
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