Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Am. J. Epidemiol.
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Vaughn, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vaughn, D. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology, Vol 152, Issue 9 800-803, Copyright © 2000 by Oxford University Press

Invited commentary: Dengue lessons from Cuba [In Process Citation]

DW Vaughn
Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. david.vaughn@na.amedd.army.mil

An 18-year interval between a dengue virus type 1 outbreak in 1977-1979 and a dengue virus type 2 outbreak in 1997 in Santiago de Cuba, Cuba, provided a unique opportunity to evaluate risk factors for dengue disease. All patients with symptomatic dengue, including 205 cases of dengue hemorrhagic fever and 12 deaths, were adults born before the dengue virus type 1 epidemic, and nearly all (98%) experienced secondary dengue virus infections. In contrast, almost all of those who seroconverted without illness (97%) experienced primary dengue virus infection. This provides epidemiologic support for the immune enhancement theory of dengue pathogenesis. The Cuban experience suggests that immune enhancement can be seen even 20 years after the primary dengue virus infection. It also supports the contention that primary infections with dengue virus type 2 (and dengue virus type 4) are largely subclinical. These observations have implications for dengue vaccine development based on live-attenuated viruses.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in Am. J. Epidemiol.:

Dr. Guzmán et al. Respond to Dr. Vaughn
Maria G. Guzmán, Gustavo Kouri, Luis Valdes, Jose Bravo, Mayling Alvarez, Susana Vazques, Iselys Delgado, and Scott B. Halstead
Am. J. Epidemiol. 2000 152: 804. [Abstract] [FREE Full Text]  



This article has been cited by other articles:


Home page
 J. Virol.Home page
K. Boonnak, B. M. Slike, T. H. Burgess, R. M. Mason, S.-J. Wu, P. Sun, K. Porter, I. F. Rudiman, D. Yuwono, P. Puthavathana, et al.
Role of Dendritic Cells in Antibody-Dependent Enhancement of Dengue Virus Infection
J. Virol., April 15, 2008; 82(8): 3939 - 3951.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. V. F. Carrington, J. E. Foster, O. G. Pybus, S. N. Bennett, and E. C. Holmes
Invasion and Maintenance of Dengue Virus Type 2 and Type 4 in the Americas
J. Virol., December 1, 2005; 79(23): 14680 - 14687.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. N. HAMMOND, A. BALMASEDA, L. PEREZ, Y. TELLEZ, S. I. SABORIO, J. C. MERCADO, E. VIDEA, Y. RODRIGUEZ, M. A. PEREZ, R. CUADRA, et al.
DIFFERENCES IN DENGUE SEVERITY IN INFANTS, CHILDREN, AND ADULTS IN A 3-YEAR HOSPITAL-BASED STUDY IN NICARAGUA
Am J Trop Med Hyg, December 1, 2005; 73(6): 1063 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 JWatch Infect. DiseasesHome page
Cuban Study: Prior Dengue Infection Means Risk for Symptomatic Reinfection
Journal Watch Infectious Diseases, January 11, 2001; 2001(111): 3 - 3.
[Full Text]

Home page
 Am J EpidemiolHome page
M. G. Guzman, G. Kouri, L. Valdes, J. Bravo, M. Alvarez, S. Vazques, I. Delgado, and S. B. Halstead
Dr. Guzman et al. Respond to Dr. Vaughn
Am. J. Epidemiol., November 1, 2000; 152(9): 804 - 804.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.