American Journal of Epidemiology, Vol 152, Issue 8 780-787, Copyright © 2000 by Oxford University Press
HY Huang, MG Maguire, ER Miller 3rd and LJ Appel
The impact of pill organizers on pill taking was determined in the Trial of
Antioxidant Vitamins C and E (TRACE) Study, a factorial trial of vitamin C
and vitamin E supplementation in 184 individuals. Participants were
recruited in 1996-1997 and randomized to one of two groups (pill organizer
or no organizer) and to one of four supplement groups for 2 months. The
pill count (observed/expected X 100%) distribution was similar in the
organizer and no organizer group for both vitamins. Mean differences in
changes in serum vitamin levels between active and placebo groups did not
differ by pill organizer use. The impact of pill organizers and blister
packs was compared in another trial, the Vitamins, Teachers, and Longevity
(VITAL) Study, in 297 individuals randomized in 1993-1994 to receive study
pills either in blister packs or in pill organizers and to take one of two
supplements. Among those with lower adherence, the pill count distribution
in the blister-pack group exceeded that in the organizer group. Mean
differences in serum vitamin E levels between active and placebo groups did
not differ by types of pill packaging. In summary, use of blister packs,
but not pill organizers, improved adherence as measured by pill counts
among those with lower adherence. Neither pill delivery system improved
adherence as measured by serum vitamin levels.
Impact of pill organizers and blister packs on adherence to pill taking in two vitamin supplementation trials [In Process Citation]
Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205-2223, USA. hyhuang@jhsph.edu
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