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American Journal of Epidemiology, Vol 152, Issue 8 747-751, Copyright © 2000 by Oxford University Press

Dose response of laboratory markers to alcohol consumption in a general population [In Process Citation]

P Sillanaukee, N Massot, P Jousilahti, E Vartiainen, J Sundvall, U Olsson, K Poikolainen, M Ponnio, JP Allen and H Alho
Alcohol-related Diseases, Pharmacia & Upjohn Diagnostics AB, Uppsala, Sweden. Pekka.Sillanaukee@finnish-immunotech.com

The dose response to alcohol use of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and their combination (gamma- CDT) was studied in an age- and gender-stratified, random sample from Finland in 1997. A linear association with a threshold between alcohol consumption and the three markers was observed. Body mass index was negatively associated with CDT and positively with GGT Age was positively associated with GGT and gamma-CDT In conclusion, CDT appears to be an early phase marker of alcohol consumption. The combined marker, gamma-CDT, was less associated with factors such as body mass index but more strongly correlated with alcohol consumption than were the two markers separately.
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