American Journal of Epidemiology, Vol 152, Issue 8 693-700, Copyright © 2000 by Oxford University Press
X Wang, D Chen, T Niu, Z Wang, L Wang, L Ryan, T Smith, DC Christiani, B Zuckerman and X Xu
This study investigated whether the association between low level benzene
exposure and shortened gestation is modified by two susceptibility genes,
CYP1A1 and GSTT1. This report includes 542 (302 nonexposed, 240
benzene-exposed) nonsmoking and nondrinking mothers of singleton live
births at Beijing Yanshan Petrochemical Corporation between June 1995 and
June 1997. Epidemiologic and clinical data and blood samples were obtained
from mothers. Multiple linear regression models were used to estimate the
associations of benzene exposure and genetic susceptibility with
gestational age, adjusting for maternal age, education, parity, stress,
passive smoking, prepregnancy weight and height, and infant's sex. Without
consideration of genotype, benzene exposure was associated with a decrease
in mean gestational age of 0.29 (standard error (SE), 0.12) week. When
stratified by the maternal CYP1A1 genotype, the estimated decrease was 0.54
(SE, 0.12) week for the AA group, which was significantly greater (p =
0.003) than that for the Aa/aa group, which showed no decrease in
gestational age. When both CYP1A1 and GSTT1 were considered, the greatest
decrease was found among exposed mothers with the CYP1A1 AA-GSTT1 absent
group (0.79 (SE, 0.25) week) and the CYP1A1 AA-GSTT1 present group (0.50
(SE, 0.22) week). Among the nonexposed, genetic susceptibility alone did
not confer a significant adverse effect. This study provides evidence of
gene-environment interaction and supports further assessment of the role of
genetic susceptibility in the evaluation of reproductive toxins.
Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction [In Process Citation]
Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, MA 02118, USA. xbwang@bu.edu
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