American Journal of Epidemiology, Vol 152, Issue 7 666-673, Copyright © 2000 by Oxford University Press
NH Dukers, SM Bruisten, JA van den Hoek, JB de Wit, GJ van Doornum and RA Coutinho
The objective of this study was to evaluate whether the change in sexual
behavior among homosexual men observed after the start of the acquired
immunodeficiency syndrome epidemic resulted in a change in herpes simplex
virus (HSV) seroprevalence in this group over time. In a cross-sectional
study, the prevalence of herpesvirus types 1 (HSV1) and 2 (HSV2) was
determined at study entry in 1984-1985 and 1995-1997 among 532 young (aged
< or = 30 years) homosexual men participating in the Amsterdam Cohort
Studies on HIV/AIDS. Risk factors for the presence of HSV antibodies,
including human immunodeficiency virus infection, were evaluated, and their
influence on HSV prevalence over time was assessed. A strong decrease in
HSV1 and HSV2 seroprevalence, from 80.6% to 59.0% and from 51.3% to 19.0%,
respectively, was observed between the two time periods. This decrease was
not markedly influenced by various demographic and socioeconomic factors.
After data were controlled for several markers of sexual activity (such as
number of sex partners, human immunodeficiency virus infection, and past
episode(s) of gonorrhea), it appeared that the decline in HSV
seroprevalence was explained by a concurrent decrease in the presence of
these markers. The authors conclude that among young homosexual men in this
study, the strong decrease in HSV seroprevalence was associated with a
concurrent shift in sexual behavior. Furthermore, these data suggest an
increasing sexual component in HSV1 transmission over time.
ARTICLES
Strong decline in herpes simplex virus antibodies over time among young homosexual men is associated with changing sexual behavior
Division of Public Health and Environment, Municipal Health Service Amsterdam, The Netherlands. ndukers@gggd.amsterdam.nl
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