American Journal of Epidemiology, Vol 152, Issue 5 420-423, Copyright © 2000 by Oxford University Press
S Sato, M Nakamura, M Iida, Y Naito, A Kitamura, T Okamura, Y Nakagawa, H Imano, M Kiyama, H Iso, T Shimamoto and Y Komachi
There is little information on the relation of plasma fibrinogen
concentration to the risk of coronary heart disease in Asians, including
Japanese, whose plasma fibrinogen concentration has been reported to be low
by Western standards. The authors conducted a prospective study with 4.8
years of follow-up of 11,977 men and women aged 21-89 years (mean value of
fibrinogen = 267 mg/dl) living or working in Osaka, Japan, in 1990-1996 to
examine the relation of plasma fibrinogen with the incidence of coronary
heart disease (myocardial infarction and angina pectoris). Mean fibrinogen
concentration was 293.6 mg/dl for men who developed coronary heart disease
(n = 35) compared with 261.6 mg/dl for men free of coronary heart disease
(n = 8,094; difference, p < 0.01), and 355.2 mg/dl for women who
developed coronary heart disease (n = 6) compared with 276.8 mg/dl for
women free of coronary heart disease (n = 3,842; difference, p < 0.01).
With a Cox proportional hazards model to adjust for cardiovascular risk
factors, the relative risk for the highest fibrinogen quartile (> or
=295 mg/dl) compared with the lowest (<228 mg/dl) was 4.8 (95%
confidence interval: 1.4, 16.8, p = 0.01) for coronary heart disease, and
3.8 (95% confidence interval: 1.1, 13.4, p = 0.04) for myocardial
infarction. Plasma fibrinogen is useful to predict the risk of coronary
heart disease among urban Japanese, whose mean plasma fibrinogen is
relatively low.
ARTICLES
Plasma fibrinogen and coronary heart disease in urban Japanese
Department of Epidemiology and Mass Examination, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
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