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American Journal of Epidemiology Vol. 150, No. 9: 963-968
Copyright © 1999 by The Johns Hopkins University School of Hygiene and Public Health

other

Is Age-related Maculopathy Associated with Alzheimer's Disease?: The Rotterdam Study

Caroline C. W. Klaver1,2, Alewijn Ott1, Albert Hofman1, Jacqueline J. M. Assink1,3, Monique M. B. Breteler1 and Paulus T. V. M. de Jong1,3,4

1Department of Epidemiology and Biostatistics, Erasmus University Medical School Rotterdam, the Netherlands
2Department of Ophthalmology, Erasmus University Medical School Rotterdam, the Netherlands
3The Netherlands Ophthalmic Research Institute Amsterdam, the Netherlands
4Department of Ophthalmology, Academic Medical Center Amsterdam, the Netherlands

The authors examined the relation between age-related maculopathy and Alzheimer's disease in the Rotterdam Study, a prospective population-based study in the Netherlands. From 1990 to mid-1993, subjects aged 75 years or older (n = 1,438) were screened for the presence of age-related maculopathy and Alzheimer's disease, and follow-up examinations were conducted from mid-1993 to the end of 1994. Subjects with advanced age-related maculopathy at baseline showed an increased risk of incident Alzheimer's disease (relative risk = 2.1, 95% confidence interval: 1.1, 4.3; adjusted for age and gender), but this risk decreased after additional adjustment for smoking and atherosclerosis (relative risk = 1.5, 95% confidence interval: 0.6, 3.5). These findings suggest that the neuronal degeneration occurring in age-related maculopathy and Alzheimer's disease may, to some extent, have a common pathogenesis. Am J Epidemiol 1999;150:963-8.

aging; Alzheimer disease; atherosclerosis; comorbidity; incidence; macular degeneration; neurodegenerative diseases; smoking


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