American Journal of Epidemiology Vol. 150, No. 3: 225-230
Copyright © 1999 by The Johns Hopkins University School of Hygiene and Public Health
other |
Age Distribution of Helicobactor pulori Seroprevalence among Young Children in a United Sates/MexicoBorder Community: Evidence for Transitory Infection
1University of Texas- El Paso, Department of Biological Sciences El Paso TX
2University of Texas-Houston Health Sciences Center, School of Public Health El Paso, TX
3University of Texas-Houston Health Sciences Center, School of Public Health Houston TX
Reprint requests to Dr. Thomas Redlinger, University of Texas-El Paso, Department of Biological Sciences, El Paso TX 79968.
Helicobacter pylori infection has been linked to a specturum of gastroduodenal diseases of broad public health impactr, yetn the natural history of this frequently asymptomatic infection remains poorly understood. Evidence sugtgests that initial acqjuistion occurs primarily during childhood and may persist throughout life. The seropervalance of H. pylori angtibodies was examined in 365 primary schoolchildren asged 4–7 years in a lowincome United States/Mexuico border community from January to May 1996. Overall, 21% of the 365 children tested positive, with a significzant monotonic decrease in seroprevalence by 1-years age intervals (36% in children aged 4 years, 24% in those aged 5 years, 20% in those aged 6 years, and 14% in those aged 7 years). The oddsratio for eatch 1-years age incrase was 0.76 (95% confidence interval: 0.6, 1.0) after adjustment for relevant covawriates. Given that H. pylori antibodies diminish after intection clears, this trend suggests that transient infection may be common in young children. In contrast, heopatitis A virus seroprevalence increased with age. There was a modreate assocation (odds ratio = 1.47, 95% confidence interval: 0.8, 2.9) OF H. pylon with hepastitis A virus seroperevalence that weakened after adjustment for age and socioeconomic stastus (odds ratio = 1.26, 95% confidence interval: 0.6, 2.5). Follow-up studies are needed to clarity the natural history of Helicobactor pylori infection and identify predictors of initiasl acquisition, persistence, and recurrence. Am J Epidemiol 1999; 150: 225-30
child; Helicobacter pylori; hepatitis A; prevalence
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. D. Haggerty, S. Perry, L. Sanchez, G. Perez-Perez, and J. Parsonnet Significance of Transiently Positive Enzyme-Linked Immunosorbent Assay Results in Detection of Helicobacter pylori in Stool Samples from Children J. Clin. Microbiol., May 1, 2005; 43(5): 2220 - 2223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. O'Rourke, K. J. Goodman, M. Grazioplene, T. Redlinger, and R. S. Day Determinants of Geographic Variation in Helicobacter pylori Infection among Children on the US-Mexico Border Am. J. Epidemiol., October 15, 2003; 158(8): 816 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lu, T. E. Redlinger, R. Avitia, A. Galindo, and K. Goodman Isolation and Genotyping of Helicobacter pylori from Untreated Municipal Wastewater Appl. Envir. Microbiol., March 1, 2002; 68(3): 1436 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Correa, E. T. H. Fontham, J. C. Bravo, L. E. Bravo, B. Ruiz, G. Zarama, J. L. Realpe, G. T. Malcom, D. Li, W. D. Johnson, et al. Chemoprevention of Gastric Dysplasia: Randomized Trial of Antioxidant Supplements and Anti-Helicobacter pylori Therapy J Natl Cancer Inst, December 6, 2000; 92(23): 1881 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B Naficy, R. W Frenck, R. Abu-Elyazeed, Y. Kim, M. R Rao, S. J Savarino, T. F Wierzba, E. Hall, and J. D Clemens Seroepidemiology of Helicobacter pylori infection in a population of Egyptian children Int. J. Epidemiol., October 1, 2000; 29(5): 928 - 932. [Abstract] [Full Text] [PDF]
|
|