American Journal of Epidemiology Vol. 150, No. 11: 1129-1137
Copyright © 1999 by The Johns Hopkins University School of Hygiene and Public Health
other |
Interaction between Tobacco and Alcohol Consumption and the Risk of Cancers of the Upper Aero-Digestive Tract in Brazil
1Departments of Oncology and Epidemiology, McGill University Montreal, Canada
2A. C. Camargo Hospital Säo Paulo, Brazil
3Erasto Gaertner Hospital Curitiba, Brazil
4Arauio Jorae Hospital Goiânia. Brazil
Reprint requests to Dr. Eduardo L. Franco, Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec, Canada H2W 1 S6.
The authors investigated the joint effects of tobacco and alcohol consumption on the risk of squamous cell carcinomas of the upper aero-digestive tract (UADT) using data from a hospital-based case-control study conducted in southern Brazil, 1986-1989. A total of 784 cases of cancers of the mouth, pharynx, and larynx and 1,578 non-cancer controls matched on age, sex, hospital catchment area, and period of admission were interviewed about their smoking and drinking habits and other characteristics. Using logistic regression, evidence was found for interaction between the cumulative exposures for smoking and alcohol on UADT cancer risk. The joint effects for pharyngeal cancers exceeded the levels expected under a multiplicative model for moderate smokers (p = 0.007). There was little statistical evidence, however, for interaction on cancers of the mouth (p = 0.28) or larynx (p = 0.95). Among never smokers, heavy drinkers had 9.2 times (95% confidence interval 1.7, 48.5) greater risk of cancers of mouth, pharynx, and supraglottis than never drinkers, with a dose-response trend (p = 0.013) with cumulative consumption. The authors conclude that the interaction occurring in the pharynx between smoking and alcohol on UADT cancers is not uniform, with varying effects depending on the level of smoking exposure. Alcohol may act as both a promoter for tobacco and as an independent risk factor. Am J Epidemiol 1999; 150:1129-37.
alcohol drinking; case-control studies; epidemiologic methods; hedd and neck neoplasms; larnx; mouth; pharynk; smoking
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y.-T. HO, C.-C. LU, J.-S. YANG, J.-H. CHIANG, T.-C. LI, S.-W. IP, T.-C. HSIA, C.-L. LIAO, J.-G. LIN, W. G. WOOD, et al. Berberine Induced Apoptosis via Promoting the Expression of Caspase-8, -9 and -3, Apoptosis-inducing Factor and Endonuclease G in SCC-4 Human Tongue Squamous Carcinoma Cancer Cells Anticancer Res, October 1, 2009; 29(10): 4063 - 4070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Lotrean, S. Kremers, C. Ionut, and H. de Vries Gender differences regarding the alcohol-tobacco relationship among Romanian adolescents--a longitudinal study Eur J Public Health, June 1, 2009; 19(3): 285 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Webb and M. P. Carey The early health consequences of smoking: Relationship with psychosocial factors among treatment-seeking Black smokers Nicotine Tob Res, May 1, 2009; 11(5): 564 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Purdue, M. Hashibe, J. Berthiller, C. La Vecchia, L. D. Maso, R. Herrero, S. Franceschi, X. Castellsague, Q. Wei, E. M. Sturgis, et al. Type of Alcoholic Beverage and Risk of Head and Neck Cancer--A Pooled Analysis Within the INHANCE Consortium Am. J. Epidemiol., January 15, 2009; 169(2): 132 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Boccia, M. Hashibe, P. Galli, E. De Feo, T. Asakage, T. Hashimoto, A. Hiraki, T. Katoh, T. Nomura, A. Yokoyama, et al. Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 248 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hashibe, P. Brennan, S. Benhamou, X. Castellsague, C. Chen, M. P. Curado, L. D. Maso, A. W. Daudt, E. Fabianova, V. Wunsch-Filho, et al. Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium J Natl Cancer Inst, May 16, 2007; 99(10): 777 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Jayaprakash, N. R. Rigual, K. B. Moysich, T. R. Loree, M. A. S. Nasca, R. J. Menezes, and M. E. Reid Chemoprevention of head and neck cancer with aspirin: a case-control study. Arch Otolaryngol Head Neck Surg, November 1, 2006; 132(11): 1231 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Maserejian, K. J. Joshipura, B. A. Rosner, E. Giovannucci, and A. I. Zavras Prospective study of alcohol consumption and risk of oral premalignant lesions in men. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 774 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. N. Nishimoto, N. A. Pinheiro, S. R. Rogatto, A. L. Carvalho, R. Pereira de Moura, O. L. Caballero, A. Simpson, and L. P. Kowalski Alcohol Dehydrogenase 3 Genotype as a Risk Factor for Upper Aerodigestive Tract Cancers Arch Otolaryngol Head Neck Surg, January 1, 2004; 130(1): 78 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Geisler and A. F. Olshan GSTM1, GSTT1, and the Risk of Squamous Cell Carcinoma of the Head and Neck: A Mini-HuGE Review Am. J. Epidemiol., July 15, 2001; 154(2): 95 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Waddell, P. S. Levy, N. F. Schlecht, and E. L. Franco RE: "INTERACTION BETWEEN TOBACCO AND ALCOHOL CONSUMPTION AND THE RISK OF CANCERS OF THE UPPER AERO-DIGESTIVE TRACT IN BRAZIL" Am. J. Epidemiol., July 15, 2000; 152(2): 193 - 193. [Full Text] [PDF]
|
|