American Journal of Epidemiology Vol. 149, No. 5: 454-462
Copyright © 1999 by The Johns Hopkins University School of Hygiene and Public Health
other |
Influence of a Family History of Cancer Within and Across Multiple Sites on Patterns of Cancer Mortality Risk for Women
1University of Colorado Health Sciences Center Denver, CO
2American Cancer Society Atlanta, GA
A case-control study nested within a large cohort, the American Cancer Society Cancer Prevention Study-1, was conducted to test associations between a family history of cancer and cancer mortality in women. By using logistic regression, the authors analyzed family history, as reported by 429, 483 women enrolled in 1959, relative to subsequent mortality through 1972 from cancer within and across multiple sites. The associations between family history and cancer mortality were generally stronger within cancer sites than across cancer sites. Within-site associations were found for breast cancer (odds ratio (OR) = 1.9), colorectal cancer (OR = 1.6), stomach cancer (OR = 1.9), and lung cancer (OR = 1.7). Across-site associations were observed for a family history of 1) breast cancer as a risk factor for ovarian cancer mortality (OR = 1.6), 2) stomach cancer as a risk factor for ovarian cancer mortality (OR = 1.5), and 3) uterine cancer as a risk factor for pancreatic cancer mortality (OR = 1.6). A general pattern of positive associations was observed between a family history of cancer at several sites and subsequent death from pancreatic cancer. These findings support the growing body of evidence from cancer genetics suggesting that inherited cancer-susceptibility genes increase the risk for cancer at many sites and are not specific to cancer risk within a single site. Am J Epidemiol 1999; 149:454–62.
cohort studies; family characteristics; genes; mortality; neoplasms; women
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Zhang, X.-O. Shu, Y.-T. Gao, B.-T. Ji, G. Yang, H. L. Li, B. Kilfoy, N. Rothman, W. Zheng, and W.-H. Chow Family History of Cancer and Risk of Lung Cancer among Nonsmoking Chinese Women Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2432 - 2435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-i. Nitadori, M. Inoue, M. Iwasaki, T. Otani, S. Sasazuki, K. Nagai, S. Tsugane, and the JPHC Study Group Association Between Lung Cancer Incidence and Family History of Lung Cancer: Data From a Large-Scale Population-Based Cohort Study, the JPHC Study. Chest, October 1, 2006; 130(4): 968 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Andrieu, G Launoy, R Guillois, C Ory-Paoletti, and M Gignoux Estimation of the familial relative risk of cancer by site from a French population based family study on colorectal cancer (CCREF study) Gut, September 1, 2004; 53(9): 1322 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Rauscher, D. P. Sandler, C. Poole, J. Pankow, B. Mitchell, C. D. Bloomfield, and A. F. Olshan Family History of Cancer and Incidence of Acute Leukemia in Adults Am. J. Epidemiol., September 15, 2002; 156(6): 517 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schenk, A. G. Schwartz, E. O'Neal, M. Kinnard, J. K. Greenson, J. P. Fryzek, G. S. Ying, and D. H. Garabrant Familial Risk of Pancreatic Cancer J Natl Cancer Inst, April 18, 2001; 93(8): 640 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Bromen, H. Pohlabeln, I. Jahn, W. Ahrens, and K.-H. Jockel Aggregation of Lung Cancer in Families: Results from a Population-based Case-Control Study in Germany Am. J. Epidemiol., September 15, 2000; 152(6): 497 - 505. [Abstract] [Full Text] [PDF]
|
|