American Journal of Epidemiology Vol. 149, No. 1: 32-40
Copyright © 1999 by The Johns Hopkins University School of Hygiene and Public Health
other |
Traumatic Brain Injury and Time to Onset of Alzheimer's Disease: A Population-based Study
1Department of Health Sciences Research, Mayo Clinic Rochester, MN
2Policy Analysis Division, Faculty of Commerce and Business Administration, University of British Columbia, Vancouver British Columbia, Canada
3Department of Neurology, Mayo Clinic Rochester, MN
4Houston School of Public Health, University of Texas Houston, TX
Controversy continues as to whether traumatic brain injury is a risk factor for Alzheimer's disease. The authors examined a related hypothesis that among persons with traumatic brain injury who develop Alzheimer's disease, time to onset of the disease is reduced. They used data on all documented episodes of traumatic brain injury that occurred from 1935 to 1984 among Olmsted County, Minnesota, residents. Community-based medical records were used to follow traumatic brain injury cases who were aged 40 years or older at last contact prior to June 1, 1988, for Alzheimer's disease until last contact, death, or June 1, 1988. The test of the hypothesis was restricted to those cases who developed Alzheimer's disease. The expected time to onset of Alzheimer's disease was derived from a life table constructed by using age-of-onset distributions within sex groups for a previously identified cohort of Rochester, Minnesota, Alzheimer's disease incidence cases without a history of head trauma. The authors found that of the 1,283 traumatic brain injury cases followed, 31 developed Alzheimer's disease, a number similar to that expected (standardized incidence ratio = 1.2, 95% confidence interval 0.8–1.7). However, the observed time from traumatic brain injury to Alzheimer's disease was less than the expected time to onset of Alzheimer's disease (median = 10 vs. 18 years, p = 0.015). The results suggest that traumatic brain injury reduces the time to onset of Alzheimer's disease among persons at risk of developing the disease. Am J Epidemiol 1999;149:32–40.
Alzheimer's disease; brain injuries; cohort studies; head injuries; incidence; medical records; risk factors; traumatology
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Isoniemi, T. Kurki, O. Tenovuo, V. Kairisto, and R. Portin Hippocampal volume, brain atrophy, and APOE genotype after traumatic brain injury. Neurology, September 12, 2006; 67(5): 756 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M Cameron, E V Kliewer, D M Purdie, and R J McClure Long term health outcomes after injury in working age adults: a systematic review. J Epidemiol Community Health, April 1, 2006; 60(4): 341 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-L. Siren, K. Radyushkin, S. Boretius, D. Kammer, C.-C. Riechers, O. Natt, D. Sargin, T. Watanabe, S. Sperling, T. Michaelis, et al. Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin Brain, February 1, 2006; 129(2): 480 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Salmond, D. A. Chatfield, D. K. Menon, J. D. Pickard, and B. J. Sahakian Cognitive sequelae of head injury: involvement of basal forebrain and associated structures Brain, January 1, 2005; 128(1): 189 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-H. Chen, R. Siman, A. Iwata, D. F. Meaney, J. Q. Trojanowski, and D. H. Smith Long-Term Accumulation of Amyloid-{beta}, {beta}-Secretase, Presenilin-1, and Caspase-3 in Damaged Axons Following Brain Trauma Am. J. Pathol., August 1, 2004; 165(2): 357 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Helmuth Detangling Alzheimer's Disease Sci. Aging Knowl. Environ., October 29, 2003; 2003(43): oa2 - 2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Millar, J A R Nicoll, S Thornhill, G D Murray, and G M Teasdale Long term neuropsychological outcome after head injury: relation to APOE genotype J. Neurol. Neurosurg. Psychiatry, August 1, 2003; 74(8): 1047 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Fleminger, D L Oliver, S Lovestone, S Rabe-Hesketh, and A Giora Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 857 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Bower, D. M. Maraganore, B. J. Peterson, S. K. McDonnell, J. E. Ahlskog, and W. A. Rocca Head trauma preceding PD: A case-control study Neurology, May 27, 2003; 60(10): 1610 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Malaspina, R. R. Goetz, J. H. Friedman, C. A. Kaufmann, S. V. Faraone, M. Tsuang, C. R. Cloninger, J. I. Nurnberger Jr., and M. C. Blehar Traumatic Brain Injury and Schizophrenia in Members of Schizophrenia and Bipolar Disorder Pedigrees Am J Psychiatry, March 1, 2001; 158(3): 440 - 446. [Abstract] [Full Text]
|
|
|
|
|
|
O.L. Lopez, J.T. Becker, W. Klunk, J. Saxton, R.L. Hamilton, D.I. Kaufer, R.A. Sweet, C. Cidis Meltzer, S. Wisniewski, M.I. Kamboh, et al. Research evaluation and diagnosis of possible Alzheimer's disease over the last two decades: II Neurology, December 26, 2000; 55(12): 1863 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Plassman, R. J. Havlik, D. C. Steffens, M. J. Helms, T. N. Newman, D. Drosdick, C. Phillips, B. A. Gau, K. A. Welsh-Bohmer, J. R. Burke, et al. Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias Neurology, October 24, 2000; 55(8): 1158 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Mehta, A. Ott, S. Kalmijn, A. J. C. Slooter, C. M. van Duijn, A. Hofman, and M. M. B. Breteler Head trauma and risk of dementia and Alzheimer's disease: The Rotterdam Study Neurology, December 1, 1999; 53(9): 1959 - 1959. [Abstract] [Full Text] [PDF]
|
|