American Journal of Epidemiology Vol. 148, No. 2: 204-214
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study
1Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, Wl
4Department of Preventive Medicine, University of Wisconsin Madison, Wl
Reprint requests to Dr. Julie Mares-Perlman, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, 405 WARF, Madison, WI 53705-2397
Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administered at baseline (1988–1990) to collect dietary information for that time period and a period of time 10 years earlier (1978–1980) from a 50 percent random sample of persons participating in this study. The incidence of the specific lesions of larger drusen (>125 µ) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations. Significant, but modest, inverse associations (p < 0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities. No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM. If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. However, because there were too few incident late ARM cases in this cohort, the authors were unable to assess whether antioxidant intake is associated with the progression of early ARM to late-stage macular degeneration. Clinical trials and longer-term prospective studies are needed to elucidate further the impact of antioxidants and zinc on the development and progression of ARM. Am J Epidemiol 1998;148:204–14.
antioxidants; diet; maculopathy; age-related; retina; retinal degeneration
2Current address: Department of Health and Sports Science, University of Richmond, Richmond, VA.
3Current address: Organon, Inc., West Orange, NJ.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C-J Chiu, R Klein, R C Milton, G Gensler, and A Taylor Does eating particular diets alter the risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements? Br J Ophthalmol, September 1, 2009; 93(9): 1241 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Loane, C Kelliher, S Beatty, and J M Nolan The rationale and evidence base for a protective role of macular pigment in age-related maculopathy Br J Ophthalmol, September 1, 2008; 92(9): 1163 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Jager, W. F. Mieler, and J. W. Miller Age-Related Macular Degeneration N. Engl. J. Med., June 12, 2008; 358(24): 2606 - 2617. [Full Text] [PDF]
|
|
|
|
 |
|
 E. D O'Connell, J. M Nolan, J. Stack, D. Greenberg, J. Kyle, L. Maddock, and S. Beatty Diet and risk factors for age-related maculopathy Am. J. Clinical Nutrition, March 1, 2008; 87(3): 712 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Age-Related Eye Disease Study Research Group The Relationship of Dietary Carotenoid and Vitamin A, E, and C Intake With Age-Related Macular Degeneration in a Case-Control Study: AREDS Report No. 22 Arch Ophthalmol, September 1, 2007; 125(9): 1225 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Iannaccone, M. Mura, K. T. Gallaher, E. J. Johnson, W. A. Todd, E. Kenyon, T. L. Harris, T. Harris, S. Satterfield, K. C. Johnson, et al. Macular Pigment Optical Density in the Elderly: Findings in a Large Biracial Midsouth Population Sample Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1458 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R E Hogg, R S Anderson, M R Stevenson, M B Zlatkova, and U Chakravarthy In vivo macular pigment measurements: a comparison of resonance Raman spectroscopy and heterochromatic flicker photometry Br J Ophthalmol, April 1, 2007; 91(4): 485 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Nolan, J. Stack, E. O'Connell, and S. Beatty The Relationships between Macular Pigment Optical Density and Its Constituent Carotenoids in Diet and Serum Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 571 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M Seddon Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract Am. J. Clinical Nutrition, January 1, 2007; 85(1): 304S - 307S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Gorin A Clinician's View of the Molecular Genetics of Age-Related Maculopathy Arch Ophthalmol, January 1, 2007; 125(1): 21 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Rosenthal, J. Kim, F. de Monastario, D. J. S. Thompson, R. A. Bone, J. T. Landrum, F. F. de Moura, F. Khachik, H. Chen, R. L. Schleicher, et al. Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or Older Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5227 - 5233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R Trumbo and K. C Ellwood Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 971 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Moeller, N. Parekh, L. Tinker, C. Ritenbaugh, B. Blodi, R. B. Wallace, J. A. Mares, and for the CAREDS Research Study Group Associations Between Intermediate Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS): Ancillary Study of the Women's Health Initiative. Arch Ophthalmol, August 1, 2006; 124(8): 1151 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Osborne and J. P. M. Wood The {beta}-Adrenergic Receptor Antagonist Metipranolol Blunts Zinc-Induced Photoreceptor and RPE Apoptosis. Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 3178 - 3186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Whitehead, J. A. Mares, and R. P. Danis Macular Pigment: A Review of Current Knowledge Arch Ophthalmol, July 1, 2006; 124(7): 1038 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Delcourt, I. Carriere, M. Delage, P. Barberger-Gateau, W. Schalch, and the POLA Study Group Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study. Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2329 - 2335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Mares and S. M Moeller Diet and age-related macular degeneration: expanding our view. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 733 - 734. [Full Text] [PDF]
|
|
|
|
 |
|
 R. van Leeuwen, S. Boekhoorn, J. R. Vingerling, J. C. M. Witteman, C. C. W. Klaver, A. Hofman, and P. T. V. M. de Jong Dietary Intake of Antioxidants and Risk of Age-Related Macular Degeneration JAMA, December 28, 2005; 294(24): 3101 - 3107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Seddon, S. George, B. Rosner, and N. Rifai Progression of Age-Related Macular Degeneration: Prospective Assessment of C-Reactive Protein, Interleukin 6, and Other Cardiovascular Biomarkers Arch Ophthalmol, June 1, 2005; 123(6): 774 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Seddon, J. Cote, W. F. Page, S. H. Aggen, and M. C. Neale The US Twin Study of Age-Related Macular Degeneration: Relative Roles of Genetic and Environmental Influences Arch Ophthalmol, March 1, 2005; 123(3): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho, J. M. Seddon, B. Rosner, W. C. Willett, and S. E. Hankinson Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoids and Risk of Age-Related Maculopathy Arch Ophthalmol, June 1, 2004; 122(6): 883 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E Millen, R. Klein, A. R Folsom, J. Stevens, M. Palta, and J. A Mares Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study Am. J. Clinical Nutrition, May 1, 2004; 79(5): 865 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Zarbin Current Concepts in the Pathogenesis of Age-Related Macular Degeneration Arch Ophthalmol, April 1, 2004; 122(4): 598 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mares, T. L. La Rowe, and B. A. Blodi Doctor, What Vitamins Should I Take for My Eyes? Arch Ophthalmol, April 1, 2004; 122(4): 628 - 635. [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Millen, M. Gruber, R. Klein, B. E. K. Klein, M. Palta, and J. A. Mares Relations of Serum Ascorbic Acid and {alpha}-Tocopherol to Diabetic Retinopathy in the Third National Health and Nutrition Examination Survey Am. J. Epidemiol., August 1, 2003; 158(3): 225 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Gale, N. F. Hall, D. I. W. Phillips, and C. N. Martyn Lutein and Zeaxanthin Status and Risk of Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2461 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Seddon, J. Cote, N. Davis, and B. Rosner Progression of Age-Related Macular Degeneration: Association With Body Mass Index, Waist Circumference, and Waist-Hip Ratio Arch Ophthalmol, June 1, 2003; 121(6): 785 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Broekmans, T. T. Berendschot, I. A. Klopping-Ketelaars, A. J de Vries, R A. Goldbohm, L. B. Tijburg, A. F. Kardinaal, and G. van Poppel Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin Am. J. Clinical Nutrition, September 1, 2002; 76(3): 595 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. F Hall and C. R Gale Prevention of age related macular degeneration BMJ, July 6, 2002; 325(7354): 1 - 2. [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Mares-Perlman, A. E. Millen, T. L. Ficek, and S. E. Hankinson The Body of Evidence to Support a Protective Role for Lutein and Zeaxanthin in Delaying Chronic Disease. Overview J. Nutr., March 1, 2002; 132(3): 518S - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Heuberger, J. A. Mares-Perlman, R. Klein, B. E. K. Klein, A. E. Millen, and M. Palta Relationship of Dietary Fat to Age-Related Maculopathy in the Third National Health and Nutrition Examination Survey Arch Ophthalmol, December 1, 2001; 119(12): 1833 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Age-Related Eye Disease Study Research Group A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8 Arch Ophthalmol, October 1, 2001; 119(10): 1417 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Christen, R. J. Glynn, U. A. Ajani, D. A. Schaumberg, E. Y. Chew, J. E. Buring, J. E. Manson, and C. H. Hennekens Age-Related Maculopathy in a Randomized Trial of Low-Dose Aspirin Among US Physicians Arch Ophthalmol, August 1, 2001; 119(8): 1143 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Grahn, P. G. Paterson, K. T. Gottschall-Pass, and Z. Zhang Zinc and the Eye J. Am. Coll. Nutr., April 1, 2001; 20(2): 106 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Marse-Perlman, A. I. Fisher, R. Klein, M. Palta, G. Block, A. E. Millen, and J. D. Wright Lutein and Zeaxanthin in the Diet and Serum and Their Relation to Age-related Maculopathy in the Third National Health and Nutrition Examination Survey Am. J. Epidemiol., March 1, 2001; 153(5): 424 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Hyun, J. H. Sohn, D. W. Ha, Y. H. Ahn, J.-Y. Koh, and Y. H. Yoon Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., February 1, 2001; 42(2): 460 - 465. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Moeller, P. F. Jacques, and J. B. Blumberg The Potential Role of Dietary Xanthophylls in Cataract and Age-Related Macular Degeneration J. Am. Coll. Nutr., October 1, 2000; 19(90005): 522S - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Fine, J. W. Berger, M. G. Maguire, and A. C. Ho Age-Related Macular Degeneration N. Engl. J. Med., February 17, 2000; 342(7): 483 - 492. [Full Text] [PDF]
|
|
|
|
 |
|
 J. R W Yates and A. T Moore Genetic susceptibility to age related macular degeneration J. Med. Genet., February 1, 2000; 37(2): 83 - 87. [Abstract] [Full Text]
|
|
|
|
|
|
C. Delcourt, J.-P. Cristol, F. Tessier, C. L. Leger, B. Descomps, L. Papoz, and and the POLA Study Group Age-related Macular Degeneration and Antioxidant Status in the POLA Study Arch Ophthalmol, October 1, 1999; 117(10): 1384 - 1390. [Abstract] [Full Text] [PDF]
|
|