American Journal of Epidemiology Vol. 148, No. 2: 133-142
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health
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Pleural Mesothelioma: Dose-Response Relation at Low Levels of Asbestos Exposure in a French Population-based Case-Control Study
1INSERM Unité 139, EA2345, Créteil France
2Institut Interuniversitaire de Médecine du Travail de Paris lle de France Paris, France
3CHI de Créteil, Créteil France
4Hôpital de la Conception Marseille, France
5Hôpital de Brabois Vandoeuvre, France
6Institut National de Recherche et de Sécurité Vandoeuvre, France
7Hôpital Sabourin Clermont Ferrand, France
8Collège national français d'anatomopathologistes spécialistes du mésothéliome (group MESOPATH) Caen, France
9Université Bordeaux II Bordeaux, France
A hospital-based case-control study of the association between past occupational exposure to asbestos and pleural mesothelioma was carried out in five regions of France. Between 1987 and 1993, 405 cases and 387 controls were interviewed. The job histories of these subjects were evaluated by a group of experts for exposure to asbestos fibers according to probability, intensity, and frequency. A cumulative exposure index was calculated as the product of these three parameters and the duration of the exposed job, summed over the entire working life. Among men, the odds ratio increased with the probability of exposure and was 1.2 (95% confidence interval (CI) 0.8–1.9) for possible exposure and 3.6 (95% CI 2.4–5.3) for definite exposure. A dose-response relation was observed with the cumulative exposure index: The odds ratio increased from 1.2 (95% CI 0.8–1.8) for the lowest exposure category to 8.7 (95% CI 4.1–18.5) for the highest. Among women, the odds ratio for possible or definite exposure was 18.8 (95% CI 4.1–86.2). We found a clear dose-response relation between cumulative asbestos exposure and pleural mesothelioma in a population-based case-control study with retrospective assessment of exposure. A significant excess of mesothelioma was observed for levels of cumulative exposure that were probably far below the limits adopted in most industrial countries during the 1980s. Am J Epidemiol 1998; 148: 133–42.
asbestos; case-control studies; mesothelioma; occupational exposure
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