American Journal of Epidemiology Vol. 147, No. 6: 563-573
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Body Weight Change and Carotid Artery Wall Thickness: The Athersclerosis Risk in comunities (ARIC) study
1Departments of Nutrition and epdemiology, School of public Health, University of NOrth Carolina Chapel Hill, NC
2Department of Epidemilogy, School of Public Health, University of North Carolina Chapel Hill, NC
3Department of Biostatisitcs, School of Public Health, University of North Carolina Chapel Hill, NC
4Divison of Epidemilogy, School of Public Health, University of Minesota Minnapolis, MN
5Department of Public Health and Primary Health Care, University of Bergen Bergen, NOrway
Reprint requests to Dr.June stevens, Department of Nutrition anbd Epidemilogy, CB 7400, University of NOrth Carolina, Chapel Hill, NC 27599
The impact of weight change in adulthood on cardiovascular disease is controversial. This study examined the association of change in body weight, from young adulthood to middle age, with average carotid artery intimal-medial wall thickness by B-mode ultrasound measured in middle age. Participants were 13,282 men and women aged 45-64 years from the baseline examination of the Atherosclerosis Risk in Communities (ARIC) Study (1987–1989). Weight change was calculated as the difference between weigh at the baseline examination and self-reported weight at age 25. White men gained a mean of 9.7 kg; black men, 10.1 kg; white women, 12.0 kg; and black women, 20.8 kg. Weight change was positively, albeit modestly, associated with intimal-medial thickness in black men and white men and in white women, but not in black women. Adjustedfor age, examination center, smoking, education, sports activity level, height, and body mass index at age 25, the differences in intimal-medial thickness associated with a 10-kg increment in weight change were 0.016 (95% confidence interval 0.010 to 0.022) mm in white men, 0.008 (95% confidence interval 0.001 to 0.015) mm in black men, 0.013 (95% confidence interval 0.009 to 0.017) mm in white women, and 0.002 (95% confidence interval –0.002 to 0.006) mm in black women. These findings support the hypothesis that weight gain in adulthood promotes atherosclerotic changes in white men and women and in black men.
atherosclerosis; blacks; body weight; cardiovascular diseases; obesity
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Debette, N. Leone, D. Courbon, J. Gariepy, C. Tzourio, J.-F. Dartigues, K. Ritchie, A. Alperovitch, P. Ducimetiere, P. Amouyel, et al. Calf Circumference Is Inversely Associated With Carotid Plaques Stroke, November 1, 2008; 39(11): 2958 - 2965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Volcik, R. A. Barkley, R. G. Hutchinson, T. H. Mosley, G. Heiss, A. R. Sharrett, C. M. Ballantyne, and E. Boerwinkle Apolipoprotein E Polymorphisms Predict Low Density Lipoprotein Cholesterol Levels and Carotid Artery Wall Thickness but Not Incident Coronary Heart Disease in 12,491 ARIC Study Participants Am. J. Epidemiol., August 15, 2006; 164(4): 342 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chor, E. Faerstein, G. A Kaplan, J. W Lynch, and C. S Lopes Association of weight change with ethnicity and life course socioeconomic position among Brazilian civil servants Int. J. Epidemiol., February 1, 2004; 33(1): 100 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stevens, J. Cai, K. R. Evenson, and R. Thomas Fitness and Fatness as Predictors of Mortality from All Causes and from Cardiovascular Disease in Men and Women in the Lipid Research Clinics Study Am. J. Epidemiol., November 1, 2002; 156(9): 832 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stevens, Juhaeri, and J. Cai Changes in Body Mass Index Prior to Baseline among Participants Who Are Ill or Who Die during the Early Years of Follow-up Am. J. Epidemiol., May 15, 2001; 153(10): 946 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Forsblad, A Gottsater, T Matzsch, and F Lindgarde Predictors of carotid endarterectomy in middle-aged individuals Vascular Medicine, May 1, 2001; 6(2): 81 - 85. [Abstract] [PDF]
|
|
|
|
|
|
D. L. Rainwater, B. D. Mitchell, A. G. Comuzzie, J. L. VandeBerg, M. P. Stern, and J. W. MacCluer Associations among 5-Year Changes in Weight, Physical Activity, and Cardiovascular Disease Risk Factors in Mexican Americans Am. J. Epidemiol., November 15, 2000; 152(10): 974 - 982. [Abstract] [Full Text] [PDF]
|
|