Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (25)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Smith, S. J.
Right arrow Articles by Brandt-Rauf, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, S. J.
Right arrow Articles by Brandt-Rauf, P. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 147, No. 3: 302-308
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health

other

Molecular Epidemiology of p53 Protein Mutations in Workers Exposed to Vinyl Chloride

Steven J. Smith1, Yongliang Li1, Ronda Whitley1, Marie-Jeanne Marion2, Steven Partilo1, Walter P. Carney3 and Paul W. Brandt-Rauf1

1Division of Environmental Health Sciences, School of Public Health, Columbia University New York, NY
2Unité de Recherche sur les Hepatites, le SIDA, et les Retrovirus Humains INSERM, 69424 Lyon, France
3Oncogene Science Cambridge, MA

The production of mutations in cellular tumor suppressor genes such as p53 is involved in the development of many human cancers. These mutations result in the expression of mutant forms of the encoded p53 protein which can potentially serve as a biomarker for this carcinogenic process. Workers exposed to vinyl chloride who are at risk for the development of the sentinel neoplasm angiosarcoma of the liver represent a model population for the study of such a mutant p53 biomarker, since vinyl chloride is known to cause specific p53 mutations in persons with angiosarcoma of the liver. To determine the relation between vinyl chloride exposure and this p53 biomarker, the authors examined serum samples collected between 1987 and 1992 from a cohort of 225 French vinyl chloride workers and 111 unexposed controls (matched according to age, sex, race, smoking, and alcohol drinking) for the presence of mutant p53 protein, using an enzyme-linked immunosor-bent assay. Stratification of the exposed workers by quartite of vinyl chloride exposure (in estimated ppm-years) yielded a statistically significant trend of increasing odds ratios for p53 biomarker seropositivity with increasing exposure. These results suggest that this serum biomarker for mutant p53 protein is related to vinyl chloride exposure and may be an early indicator of carcinogenic risk in exposed individuals. Am J Epidemiol 1998; 147: 302–8.

epidemiology; molecular; genes, p53; hemangiosarcoma; liver neoplasms; occupational exposure; protein p53; vinyl chloride


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
D. L. Foley, J. M. Craig, R. Morley, C. J. Olsson, T. Dwyer, K. Smith, and R. Saffery
Prospects for Epigenetic Epidemiology
Am. J. Epidemiol., February 15, 2009; 169(4): 389 - 400.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
R-H Wong, P-C Chen, C-L Du, J-D Wang, and T-J Cheng
An increased standardised mortality ratio for liver cancer among polyvinyl chloride workers in Taiwan
Occup. Environ. Med., June 1, 2002; 59(6): 405 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R.-H. Wong, C.-L. Du, J.-D. Wang, C.-C. Chan, J.-C. J. Luo, and T.-J. Cheng
XRCC1 and CYP2E1 Polymorphisms as Susceptibility Factors of Plasma Mutant p53 Protein and Anti-p53 Antibody Expression in Vinyl Chloride Monomer-exposed Polyvinyl Chloride Workers
Cancer Epidemiol. Biomarkers Prev., May 1, 2002; 11(5): 475 - 482.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.