American Journal of Epidemiology Vol. 147, No. 2: 180-186
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health
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Prospective Association between Lipid Soluble Antioxidants and Coronary Heart Disease in Men
The Multiple Risk Factor Intervention Trial
1 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh Pittsburgh, PA.
2 Multiple Risk Factor Intervention Trial Coordinating Center, Division of Biostatistics, University of Minnesota Minneapolis, MN.
3 Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh Pittsburgh, PA.
A nested case-control study was performed using participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). The cases involved nonfatal myocardial infarction or death from coronary heart disease. Serum samples (n = 734) obtained at baseline and frozen for approximately 20 years were analyzed for the antioxidants, carotenoids, retinol, and 
-, 
-, and total tocopherol. The concentrations of antioxidants were in the expected range and their association with low density lipoprotein (LDL) cholesterol reflected their absorption and transport mechanisms. Among nonsmokers, the odds ratios (95% confidence intervals (CI)) for quartile IV versus quartile I were 1.40 (0.40–4.89), 0.77 (0.20–2.96), 1.45 (0.38–5.56), 2.34 (0.56–9.81), and 2.40 (0.52–11.07) for retinol, total carotenoids, and -, -, and total tocopherol, respectively. The equivalent odds ratios (95% CI) for smokers were 0.90 (0.34–2.41), 0.66 (0.23–1.84), 0.67 (0.21–2.13), 2.04 (0.88–4.73), and 0.52 (0.16–1.67), respectively. This analysis of antioxidant concentrations by quartiles indicated no significant association of antioxidant levels with the risk of coronary disease death or nonfatal myocardial infarction. Am J Epidemiol 1998; 147: 180–6.
carotenoids; coronary disease; prospective studies; retinoltocopherol
Reprint requests to Dr. Rhobert W. Evans, University of Pittsburgh, Graduate School of Public Health, Room 503, Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261.
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