American Journal of Epidemiology Vol. 147, No. 12: 1162-1174
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health
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Relation of Nutrition to Bone Lead and Blood Lead Levels in Middle-aged to Elderly Men
The Normative Aging Study
1Department of Epidemiology, Harvard School of Public Health Boston, MA
2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Boston, MA
3Department of Nutrition, Harvard School of Public Health Boston, MA
4Department of Environmental Health, Harvard School of Public Health Boston, MA
5The Normative Aging Study, Department of Veterans Affairs Outpatient Clinic Boston, MA
Reprint requests to Dr. Howard Hu, Channing Laboratory, 181 Longwood Ave., Boston, MA 02115.
The relations of nutritional factors to lead accumulation in the body were examined cross-sectionally among 747 men aged 49–93 years (mean 67 years) in the Normative Aging Study in 1991–1995. Means (standard deviations) for blood lead, tibia lead, and patella lead were 6.2 (4.1) µg/dl, 21.9 (13.3) µg/g, and 32.0 (19.5) µg/g, respectively. In multiple regression models adjusting for age, education level, smoking, and alcohol consumption, men in the lowest quintile of total dietary intake levels of vitamin D (including vitamin supplements) (<179 lU/day) had mean tibia and patella lead levels 5.6 µg/g and 6.0 µg/g higher than men with intake in the highest quintile (
589 lU/day). Higher calcium intake was associated with lower bone lead levels, but this relation became insignificant when adjustment was made for vitamin D. The authors also observed inverse associations of blood lead levels with total dietary intake of vitamin C and iron. When analyses were controlled for patella lead, age, smoking, and alcohol consumption, men in the lowest vitamin C intake quintile (<109 mg/day) had a mean blood lead level 1.7 µg/dl higher than men in the highest quintile (339 mg/day), while men in the lowest iron intake quintile (<10.9 mg/day) had a mean blood lead level 1.1 µg/dl higher than men in the highest quintile (23.5 mg/day). This study suggests that low dietary intake of vitamin D may increase lead accumulation in bones, while lower dietary intake of vitamin C and iron may increase lead levels in the blood. Am J Epidemiol 1998; 147:1162–74.
bone and bones; calcium; iron; lead; nutrition; spectrometry; x-ray emission; vitamin C; vitamin D
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