Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (41)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Levi, F.
Right arrow Articles by Te, V.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levi, F.
Right arrow Articles by Te, V.-C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 146, No. 9: 734-739
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Incidence of Invasive Cancers Following Squamous Cell Skin Cancer

Fabio Levi1,, Lalao Randimbison1, Carlo La Vecchia2, Georges Erler1 and Van-Cong Te1

1Registre vaudois des tumeurs, Institut universitaire de médecine sociale et préventive, Centre Hospitalier Universitaire Vaudois, Lausanne, and Registre neuchâtelois des tumeurs Neuchâtel, Switzerland
2Istituto di Ricerche Farmacologiche "Mario Negri", and Istituto di Statistica Medica e Biometria, Universitá di Milano Milan, Italy

Reprint requests to Dr. Fabio Levi, Registre vaudois des tumeurs, Institut universitaire de médecine sociale et préventive, Centre Hospitalier Universitaire Vaudois, Falaises 1, Casier 15, CH-1011 Lausanne, Switzerland

The authors describe the incidence of new primary cancers among 4,639 cases of squamous cell skin cancer (SCC) diagnosed between 1974 and 1994 in the cancer registries of the Swiss cantons of Vaud and Neuchâtel (total person-years at risk = 23,152). Overall, 729 metachronous cancers were observed versus 527.6 expected, corresponding to a standardized incidence ratio (SIR) of 1.4 (95% confidence interval (Cl) 1.3–1.5). After exclusion of skin cancers, however, 384 second primary neoplasms were observed versus 397.2 expected (SIR = 1.0). Excesses were observed for cancers of the lip (SIR = 3.1) and lung (SIR = 1.3), for basal cell (SIR = 4.3) and melanomatous skin cancers (SIR = 3.3), and non-Hodgkin's lymphomas (SIR = 1.7). Rates were elevated for cancers of the salivary glands (SIR = 4.3) and for Hodgkin's disease (SIR = 2.7), and, below age 65 years, for cancers of the lung (SIR = 1.6), breast (SIR = 1.5), and prostate (SIR % 1.8), for Hodgkin's disease (SIR = 15.8), as well as for all neoplasms except skin (SIR = 1.2; 95% Cl 1.0–1.5). The cumulative risk of basal cell skin cancer reached 17% after 15 years. The authors believe that the excesses for basal cell carcinomas and melanomas of the skin following SCC, and possibly of lymphomas, were likely attributable to common phenotypic characteristics and exposure to UV radiation. The elevated rates of lung cancer are suggestive for a role of tobacco as a cause of squamous cell skin cancer.

carcinoma; squamous cell; lung neoplasms; neoplasms; second primary; registries; salivary gland neoplasms; skin; smoking; ultraviolet rays


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 haematolHome page
J. R. Toro, P. W. Blake, M. Bjorkholm, S. Y. Kristinsson, Z. Wang, and O. Landgren
Prior history of non-melanoma skin cancer is associated with increased mortality in patients with chronic lymphocytic leukemia
Haematologica, October 1, 2009; 94(10): 1460 - 1464.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
I. Soerjomataram, W. J. Louwman, V. E. P. P. Lemmens, J. W. W. Coebergh, and E. de Vries
Are Patients with Skin Cancer at Lower Risk of Developing Colorectal or Breast Cancer?
Am. J. Epidemiol., June 15, 2008; 167(12): 1421 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
E. de Vries, I. Soerjomataram, S. Houterman, M. W. J. Louwman, and J. W. W. Coebergh
Decreased Risk of Prostate Cancer after Skin Cancer Diagnosis: A Protective Role of Ultraviolet Radiation?
Am. J. Epidemiol., April 15, 2007; 165(8): 966 - 972.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Z. Nugent, A. A. Demers, M. C. Wiseman, C. Mihalcioiu, and E. V. Kliewer
Risk of Second Primary Cancer and Death Following a Diagnosis of Nonmelanoma Skin Cancer
Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2584 - 2590.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. B. Harris, J. A. Foote, I. A. Hakim, D. L. Bronson, and D. S. Alberts
Fatty Acid Composition of Red Blood Cell Membranes and Risk of Squamous Cell Carcinoma of the Skin
Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 906 - 912.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
K. E. Smedby, H. Hjalgrim, M. Melbye, A. Torrang, K. Rostgaard, L. Munksgaard, J. Adami, M. Hansen, A. Porwit-MacDonald, B. A. Jensen, et al.
Ultraviolet Radiation Exposure and Risk of Malignant Lymphomas
J Natl Cancer Inst, February 2, 2005; 97(3): 199 - 209.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
A. M. Brewster, A. J. Alberg, P. T. Strickland, S. C. Hoffman, and K. Helzlsouer
XPD Polymorphism and Risk of Subsequent Cancer in Individuals with Nonmelanoma Skin Cancer
Cancer Epidemiol. Biomarkers Prev., August 1, 2004; 13(8): 1271 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Laurent, D. L. Mitchell, Z. Estrov, M. Lowery, S. L. Tucker, M. Talpaz, and R. Kurzrock
Impact of p210Bcr-Abl on Ultraviolet C Wavelength-induced DNA Damage and Repair
Clin. Cancer Res., September 1, 2003; 9(10): 3722 - 3730.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
D. C. Whiteman, P. Watt, D. M. Purdie, M. C. Hughes, N. K. Hayward, and A. C. Green
Melanocytic Nevi, Solar Keratoses, and Divergent Pathways to Cutaneous Melanoma
J Natl Cancer Inst, June 4, 2003; 95(11): 806 - 812.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Caldeira, I. Zehbe, R. Accardi, I. Malanchi, W. Dong, M. Giarre, E.-M. de Villiers, R. Filotico, P. Boukamp, and M. Tommasino
The E6 and E7 Proteins of the Cutaneous Human Papillomavirus Type 38 Display Transforming Properties
J. Virol., February 1, 2003; 77(3): 2195 - 2206.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
K. Hemminki and C. Dong
Subsequent Cancers After In Situ and Invasive Squamous Cell Carcinoma of the Skin
Arch Dermatol, May 1, 2000; 136(5): 647 - 651.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
J. Askling, P. Sorensen, A. Ekbom, M. Frisch, M. Melbye, B. Glimelius, and H. Hjalgrim
Is History of Squamous-Cell Skin Cancer a Marker of Poor Prognosis in Patients with Cancer?
Ann Intern Med, November 2, 1999; 131(9): 655 - 659.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. S. Kahn, L. M. Tatham, A. V. Patel, M. J. Thun, and C. W. Heath Jr
Increased Cancer Mortality Following a History of Nonmelanoma Skin Cancer
JAMA, September 9, 1998; 280(10): 910 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Jiang, H. N. Ananthaswamy, H. K. Muller, A. Ouhtit, S. Bolshakov, S. E. Ullrich, A. K. El-Naggar, and M. L. Kripke
UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53
PNAS, August 14, 2001; 98(17): 9790 - 9795.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.