American Journal of Epidemiology Vol. 146, No. 7: 552-557
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Segregation Analysis of Prostate Cancer in Sweden: Support for Dominant Inheritance
1Department of Oncology, Umea University Umea, Sweden
2Departments of Urology and Andrology, Umea University Umea, Sweden
3Department of Surgery, Karolinska Hospital Stockholm, Sweden
Reprint requests to Dr. Henrik Grfinberg, Department of Oncology, Umea University, 901 85 Umea, Sweden. (E-mail: henrik.gronberg{at}oc.umu.se)
Several epidemiologic studies have shown familial aggregation of prostate cancer. To assess the nature of familial clustering of prostate cancer, a complex segregation analysis was performed on a population-based sample of 2,857 nuclear families ascertained through an affected father diagnosed with prostate cancer in Sweden during 1959–1963. The segregation analysis, using a large, unselected population of prostate cancer families, revealed that the observed clustering of prostate cancer was best explained by a high risk allele inherited in a dominant mode, with a high population frequency (1.67%) and a moderate lifetime penetrance (63%). This study confirms the result from one earlier published segregation analysis and provides the context for interpreting the recently published linkage of hereditary prostate cancer families to chromosome 1 q 24–25.
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