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American Journal of Epidemiology Vol. 146, No. 6: 470-475
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health


research-article

Cancer Incidence among an HIV-infected Cohort

C. C. Johnson1,, T. Wilcosky2, P. Kvale1, M. Rosen3, J. Stansell4, J. Glassroth5, L. Reichman6, J. Wallace7, N. Markowitz1, J. E. Thompson2, P. Hopewell4 and the Pulmonary Complications of HIV Infection Study Group

1Henry Ford Health Sciences Center Detroit, MI
2Research Triangle Institute Research Triangle Park, NC
3Beth Israel Medical Center New York, NY
4University of California, San Francisco San Francisco, CA
5Northwestern University Chicago, IL
6University of Medicine and Dentistry of New Jersey Newark, NY
7University of California Los Angeles, Los Angeles, CA

Reprint requests to Dr. Christine Cole Johnson, Henry Ford Health Sciences Center, Division of Biostatistics and Research Epidemiology, 1 Ford Place, 3E, Detroit, MI 48202

Malignancies, particularly Kaposi's sarcoma and non-Hodgkin's lymphoma (NHL), are associated with human immunodeficiency virus (HIV) infection. Cancer incidence among 1,073 asymptomatic HIV-infected individuals from the Pulmonary Complications of HIV Infection Study cohort, persons from six states followed from 1988 to 1994, was examined. Total cancer incidence was 3.99/100 person-years; for Kaposi's sarcoma, incidence was 2.64 cases/100 person-years, and for NHL, it was 1.18 cases/100 person-years. Total cancer (n = 156 cases) was higher among nonblacks than among blacks (rate ratio = 2.8, 95% confidence interval 1.3–6.1), with similar results for Kaposi's sarcoma and NHL. The rate of lung cancer (n = 5) among white, homosexual/bisexual males was 0.18 per 100 person-years, suggesting a high risk of lung cancer. Am J Epidemiol 1997;146:470-5.

ethnic groups; HIV; homosexuality; lung neoplasms; lymphoma; non-Hodgkin's; neoplasms; sarcoma; Kaposi's; substance abuse; intravenous


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