American Journal of Epidemiology Vol. 146, No. 4: 307-314
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Breast Cancer Risk Factors According to Combined Estrogen and Progesterone Receptor Status: A Case-Control Analysis
1Department of Preventive Medicine, Seoul National University College of Medicine Seoul, Korea
2Division of Epidemiology, Aichi Cancer Center Research Institute Nagoya, Japan
3Department of Breast Surgery, Aichi Cancer Center Hospital Nagoya, Japan
4Department of Epidemiology and Public Health, Yale University School of Medicine New Haven, CT
5Formerly with the Department of Epidemiology and Public Health, Yale University School of Medicine New Haven, CT
Reprint requests to Dr. Keun-Young Yoo, Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110–799, Korea
Breast cancers demonstrate a gradient of responsiveness to endocrine therapy according to hormone receptor status, with tumors positive for both estrogen and progesterone receptors responding most favorably. The authors hypothesized that reproductive risk factors, which are probably mediated by endogenous hormones, would also differ according to receptor status, and that tumors positive for both receptors would exhibit the highest risk. Information on risk factors was obtained from 1,154 breast cancer cases and 21,714 cancer-free controls at the Aichi Cancer Center Hospital, Nagoya, Japan between 1988 and 1992. Receptor status was known for 40% of cases. For a given risk factor, odds ratios with respect to the common control group for breast cancers of differing receptor status were compared using multiple polytomous logistic regression. Risk factors did not differ significantly according to estrogen receptor status. However, age at diagnosis/interview, occupation, age at menarche, menstrual regularity at ages 20–29 years, and cigarette smoking differed significantly or borderline significantly in effect according to progesterone receptor status. Stratification of cases according to joint estrogen and progesterone receptor status indicated that estrogen receptor status did not modify this difference in effect. This study did not support the hypothesis of a gradient of risk for reproductive factors according to hormone receptor status. The authors recommend that the finding that some risk factors differ according to progesterone receptor status should be pursued in further studies. Am J Epidemiol 1997;146:307-14.
breast neoplasms; receptors; estrogen; receptors; progesterone; risk factors
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Britt, A. Ashworth, and M. Smalley Pregnancy and the risk of breast cancer Endocr. Relat. Cancer, December 1, 2007; 14(4): 907 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Zhang, I-M. Lee, J. E. Manson, N. R. Cook, W. C. Willett, and J. E. Buring Alcohol Consumption and Breast Cancer Risk in the Women's Health Study Am. J. Epidemiol., March 15, 2007; 165(6): 667 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. U. Rosenberg, K. Einarsdottir, E. I. Friman, S. Wedren, P. W. Dickman, P. Hall, and C. Magnusson Risk Factors for Hormone Receptor-Defined Breast Cancer in Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., December 1, 2006; 15(12): 2482 - 2488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Adams, C. E. Matthews, J. R. Hebert, C. G. Moore, J. E. Cunningham, X.-O. Shu, J. Fulton, Y. Gao, and W. Zheng Association of physical activity with hormone receptor status: the shanghai breast cancer study. Cancer Epidemiol. Biomarkers Prev., June 1, 2006; 15(6): 1170 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Suzuki, W. Ye, T. Rylander-Rudqvist, S. Saji, G. A. Colditz, and A. Wolk Alcohol and Postmenopausal Breast Cancer Risk Defined by Estrogen and Progesterone Receptor Status: A Prospective Cohort Study J Natl Cancer Inst, November 2, 2005; 97(21): 1601 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Nichols, A. Trentham-Dietz, J. M. Hampton, and P. A. Newcomb Oral Contraceptive Use, Reproductive Factors, and Colorectal Cancer Risk: Findings from Wisconsin Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1212 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. McDonald, M. G. Mandel, P. A. Marchbanks, S. G. Folger, J. R. Daling, G. Ursin, M. S. Simon, L. Bernstein, B. L. Strom, S. A. Norman, et al. Alcohol Exposure and Breast Cancer: Results of the Women's Contraceptive and Reproductive Experiences Study Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2106 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Althuis, J. H. Fergenbaum, M. Garcia-Closas, L. A. Brinton, M. P. Madigan, and M. E. Sherman Etiology of Hormone Receptor-Defined Breast Cancer: A Systematic Review of the Literature Cancer Epidemiol. Biomarkers Prev., October 1, 2004; 13(10): 1558 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hirose, K. Matsuo, T. Toyama, H. Iwata, N. Hamajima, and K. Tajima The CYP19 Gene Codon 39 Trp/Arg Polymorphism Increases Breast Cancer Risk in Subsets of Premenopausal Japanese Cancer Epidemiol. Biomarkers Prev., August 1, 2004; 13(8): 1407 - 1411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Al-Delaimy, E. Cho, W. Y. Chen, G. Colditz, and W. C. Willet A Prospective Study of Smoking and Risk of Breast Cancer in Young Adult Women Cancer Epidemiol. Biomarkers Prev., March 1, 2004; 13(3): 398 - 404. [Abstract] [Full Text]
|
|
|
|
|
|
G. A. Colditz, B. A. Rosner, W. Y. Chen, M. D. Holmes, and S. E. Hankinson Risk Factors for Breast Cancer According to Estrogen and Progesterone Receptor Status J Natl Cancer Inst, February 4, 2004; 96(3): 218 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cotterchio, N. Kreiger, B. Theis, M. Sloan, and S. Bahl Hormonal Factors and the Risk of Breast Cancer According to Estrogen- and Progesterone-Receptor Subgroup Cancer Epidemiol. Biomarkers Prev., October 1, 2003; 12(10): 1053 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. I. Li, K. E. Malone, P. L. Porter, N. S. Weiss, M.-T. C. Tang, and J. R. Daling The Relationship between Alcohol Use and Risk of Breast Cancer by Histology and Hormone Receptor Status among Women 65-79 Years of Age Cancer Epidemiol. Biomarkers Prev., October 1, 2003; 12(10): 1061 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Dignam, K. Wieand, K. A. Johnson, B. Fisher, L. Xu, and E. P. Mamounas Obesity, Tamoxifen Use, and Outcomes in Women With Estrogen Receptor-Positive Early-Stage Breast Cancer J Natl Cancer Inst, October 1, 2003; 95(19): 1467 - 1476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Terry and T. E. Rohan Cigarette Smoking and the Risk of Breast Cancer in Women: A Review of the Literature Cancer Epidemiol. Biomarkers Prev., October 1, 2002; 11(10): 953 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Britton, M. D. Gammon, J. B. Schoenberg, J. L. Stanford, R. J. Coates, C. A. Swanson, N. Potischman, K. E. Malone, D. J. Brogan, J. R. Daling, et al. Risk of Breast Cancer Classified by Joint Estrogen Receptor and Progesterone Receptor Status among Women 20-44 Years of Age Am. J. Epidemiol., September 15, 2002; 156(6): 507 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ursin, C.-C. Tseng, A. Paganini-Hill, S. Enger, P. C. Wan, S. Formenti, M. C. Pike, and R. K. Ross Does Menopausal Hormone Replacement Therapy Interact With Known Factors to Increase Risk of Breast Cancer? J. Clin. Oncol., February 1, 2002; 20(3): 699 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Singletary and S. M. Gapstur Alcohol and Breast Cancer: Review of Epidemiologic and Experimental Evidence and Potential Mechanisms JAMA, November 7, 2001; 286(17): 2143 - 2151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Dorgan, D. J. Baer, P. S. Albert, J. T. Judd, E. D. Brown, D. K. Corle, W. S. Campbell, T. J. Hartman, A. A. Tejpar, B. A. Clevidence, et al. Serum Hormones and the Alcohol-Breast Cancer Association in Postmenopausal Women J Natl Cancer Inst, May 2, 2001; 93(9): 710 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Anderson, K. C. Chu, N. Chatterjee, O. Brawley, and L. A. Brinton Tumor Variants by Hormone Receptor Expression in White Patients With Node-Negative Breast Cancer From the Surveillance, Epidemiology, and End Results Database J. Clin. Oncol., January 1, 2001; 19(1): 18 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Coughlin and M. Piper Genetic Polymorphisms and Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 1999; 8(11): 1023 - 1032. [Full Text]
|
|