| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
American Journal of Epidemiology Vol. 145, No. 4: 324-334
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Caffeine Intake and Delayed Conception: A European Multicenter Study on Infertility and Subfecundity
1Department of Public Health, Alicante University Spain
2Danish Epidemiology Science Centre and Department of Epidemiology and Social Medicine, Aarhus University Denmark
3Regione Lombardia, Servizio Epidemiologla e Sistema Informa-tivo Milano, Italy
Reprint requests to Prof. Francisco Bolúmar, Departamento de Salud Pública, Universidad de Alicante, Campus de San Juan, Ap. Correos 374.03080, Alicante, Spain.
The effects of caffeine consumption on delayed conception were evaluated in a European multicenter study on risk factors of infertility. Information was collected retrospectively on time of unprotected intercourse for the first pregnancy and the most recent waiting time episode in a randomly selected sample of 3,187 women aged 25–44 years from five European countries (Denmark, Germany, Italy, Poland, and Spain) between August 1991 and February 1993. The consumption of caffeinated beverages at the beginning of the waiting time was used to estimate daily caffeine intake, which was categorized as 0–100, 101–300, 301–500, and >501 mg. Risk of subfecundity (>9.5 months) and the fecundability ratio, respectively, were assessed by logistic regression and Cox proportional hazard analyses, adjusting for age, parity, smoking, alcohol consumption, frequency of intercourse, educational level, working status, use of oral contraceptives, and country. A significantly increased odds ratio (OR) of 1.45 (95% confidence interval (Cl) 1.03–2.04) for subfecundity in the first pregnancy was observed for women drinking more than 500 mg of caffeine per day, the effect being relatively stronger in smokers (OR = 1.56, 95% Cl 0.92–2.63) than in nonsmokers (OR = 1.38, 95% Cl 0.85–2.23). Women in the highest level of consumption had an increase in the time leading to the first pregnancy of 11 % (hazard ratio = 0.90, 95% Cl 0.78–1.03). These associations were observed consistently in all countries as well as for the most recent waiting time episode. The authors conclude that high levels of caffeine intake may delay conception among fertile women. Am J Epidemiol1997; 145: 324–34.
caffeine; infertility; risk factors
4Members of the European Study Group on Infertility and Sub-fecundity: Svend Juul (Denmark), Jøm Olsen (Denmark), Patrick Thonneau (France), Wilfred Karmaus (Germany), Irene Figá-Talamanca (Italy), Luigi Bisanti (Italy). Francisco Bolumar (Spain).
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. M Mikkelsen, E. E Hatch, L. A Wise, K. J Rothman, A. Riis, and H. T. Sorensen Cohort Profile: The Danish Web-based Pregnancy Planning Study--'Snart-Gravid' Int. J. Epidemiol., August 1, 2009; 38(4): 938 - 943. [Full Text] [PDF]
|
|
|
|
 |
|
 C.H. Ramlau-Hansen, A.M. Thulstrup, J.P. Bonde, J. Olsen, and B.H. Bech Semen quality according to prenatal coffee and present caffeine exposure: two decades of follow-up of a pregnancy cohort Hum. Reprod., December 1, 2008; 23(12): 2799 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Joffe, S. Paranjothy, H. Fielder, R. Lyons, and S. Palmer Use of time to pregnancy in environmental epidemiology and surveillance J. Public Health Med., June 1, 2008; 30(2): 178 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.F. Homan, M. Davies, and R. Norman The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review Hum. Reprod. Update, May 1, 2007; 13(3): 209 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Joffe, J. Key, N. Best, N. Keiding, T. Scheike, and T. K. Jensen Studying Time to Pregnancy by Use of a Retrospective Design Am. J. Epidemiol., July 15, 2005; 162(2): 115 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Jensen, M. Joffe, T. Scheike, A. Skytthe, D. Gaist, and K. Christensen Time trends in waiting time to pregnancy among Danish twins Hum. Reprod., April 1, 2005; 20(4): 955 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Klonoff-Cohen Female and male lifestyle habits and IVF: what is known and unknown Hum. Reprod. Update, March 1, 2005; 11(2): 180 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C-Y Shiau, J-D Wang, and P-C Chen Decreased fecundity among male lead workers Occup. Environ. Med., November 1, 2004; 61(11): 915 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Klonoff-Cohen, J. Bleha, and P. Lam-Kruglick A prospective study of the effects of female and male caffeine consumption on the reproductive endpoints of IVF and gamete intra-Fallopian transfer Hum. Reprod., July 1, 2002; 17(7): 1746 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Juul, W. Karmaus, and J. Olsen Regional differences in waiting time to pregnancy: pregnancy-based surveys from Denmark, France, Germany, Italy and Sweden Hum. Reprod., May 1, 1999; 14(5): 1250 - 1254. [Abstract] [Full Text] [PDF]
|
|