American Journal of Epidemiology Vol. 145, No. 11: 1020-1029
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health
other |
Melanocytic Nevi and Risk of Cutaneous Malignant Melanoma in Southern Spain
1Department of Dermatology, School of Medicine, University of Granada Granada, Spain
2Present affiliation: Department of Dermatology, Hospital General Universitario Morales Meseguer Murcia, Spain
3Division of Preventive Medicine and Public Health, University of Cantabria Santander, Spain
4Service of General Internal Medicine, Hospital Virgen de las Nieves Granada, Spain
Reprint requests to Dr. M. Delgado-Rodríguez, Division of Preventive Medicine and Public Health, University of Cantabria School of Medicine, Av. Cardenal Herrera Oria s/n, 39011-Santander, Spain.
The main objective of this study was to assess whether cutaneous malignant melanoma (CMM) shows a stronger relation with the melanocytic nevi count at the site where CMM was diagnosed than with the melanocytic nevi count at other sites, stratifying by histologic CMM type, in a southern Mediterranean population. Cases and controls were selected from a population in southern Spain in 1988–1993. The study population included 116 incident cases with non-familial CMM (International Classification of Diseases 9th Revision (ICD-9) code 172), and 116 controls matched 1: 1 for sex and age (±4 years). Data were collected by personal interview, and melanocytic nevi were counted over the entire body surface by clinical skin examination performed by a dermatologist. Crude and multiple risk factor-adjusted odds ratios and 95% confidence intervals were computed by conditional logistic regression analysis. After adjustment by skin type, unexposed skin color, and sun exposure, CMM was found to occur significantly more frequently in individuals with a high number of melanocytic nevi at the same site where CMM originated (odds ratio (OR) for >8 nevi = 12.0, 95% confidence interval (CI) 1.3–108.2). The ability to predict the number of melanocytic nevi on different anatomic sites on CMM, but exCIuding the CMM cases on each corresponding site, was also examined. A significant trend wrth the number of nevi on the anterior surface of thighs was found (OR for >4 nevi = 4.5, 95% CI 1.4–14.9). Melanocytic nevi count on the melanoma site was the variable most CIosely related to superficial spreading melanoma subtype (SSM) (OR for >8 nevi = 82.19, 95% CI 2.72–2,454). On the other hand, the number of melanocytic nevi on the melanoma site was unrelated to risk of CMM subtypes other than SSM. These results support the hypothesis that nevi are an important risk factor for melanoma, especially SSM, in populations with a darker ethnic background. Am J Epidemiol 1997;145:1020-9.
case-control studies; melanoma; nevus, pigmented
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Aalborg, J. G. Morelli, S. T. Mokrohisky, N. L. Asdigian, T. E. Byers, R. P. Dellavalle, N. F. Box, and L. A. Crane Tanning and Increased Nevus Development in Very-Light-Skinned Children Without Red Hair Arch Dermatol, September 1, 2009; 145(9): 989 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cockburn, A. Hamilton, and T. Mack The Simultaneous Assessment of Constitutional, Behavioral, and Environmental Factors in the Development of Large Nevi Cancer Epidemiol. Biomarkers Prev., February 1, 2007; 16(2): 200 - 206. [Abstract] [Full Text] [PDF]
|
|