American Journal of Epidemiology Vol. 145, No. 11: 1011-1019
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health
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Body Size and Risk of Breast Cancer
1University of Wisconsin Comprehensive Cancer Center Madison, WI
2Fred Hutchinson Cancer Research Center Seattle, WA
3Epidemiology Branch, National Institute of Environmental Health Sciences Research Triangle Park, NC
4Departments of Community and Family Medicine and Medicine, Dartmouth Medicai School Hanover, NH
5Departments of Community and Family Medicine and Medicine, Norris Cotton Cancer Center, Dartmouth Medical School Hanover, NH
6Departments of Epidemiology and Nutrition, Harvard School of Public Health; Channlng Laboratory, Harvard Medical School; and Department of Medicine, Brigham and Women's Hospital Boston, MA
Reprint requests to Dr. Amy Trentham-Dietz, University of Wisconsin Comprehensive Cancer Center, Rm. 4760, Medical Science Center, 1300 University Avenue, Madison, Wl 53706.
The relation between body size and breast cancer remains uncertain, particularly with regard to differences between pre- and postmenopausal women. The authors examined whether height, weight, body mass index, and weight change were associated with breast cancer risk among pre- and postmenopausal women. This population-based case-control study included women aged 20–74 years (n = 6,548) who were diagnosed with invasive breast cancer during 1988–1991 in Maine, Massachusetts, New Hampshire, and Wisconsin. Similarly aged control women (n = 9,057) were selected at random from driver's license files and Heaith Care Financing Administration files. Height, weight, and information on other breast cancer risk factors were ascertained by telephone interview, and logistic regression was used to estimate murtivariate-adjusted odds ratios and 95% confidence intervals. Among premenopausal women, the adjusted odds ratio for the upper quintile group of height relative to the lowest was 1.36 (95% confidence interval (Cl) 1.05–1.76). The heaviest premenopausal women had a lower risk (odds ratio (OR) = 0.87, 95% CI 0.70–1.10). Among postmenopausai women, the adjusted odds ratios were higher for the upper quintile categories of both height (OR = 1.27, 95% CI 1.11–1.45) and weight (OR = 1.57, 95% CI 1.37–1.79). Weight gain since ages 18 and 35 years was associated with increased postmenopausai breast cancer risk, and risk was lower in women wtio had lost weight. These findings suggest that programs to avoid weight gain merit study as a means to reduce risk of postmenopausai breast cancer. Am J Epidemiol 1997; 145: 1011 –19.
body height; body weight; breast neoplasms; weight gain
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