American Journal of Epidemiology Vol. 144, No. 5: 480-484
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
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Observations on Serum Uric Acid Levels and the Risk of Idiopathic Parkinson's Disease
1Hawail Osteoporosis Center Honolulu, HI
2University of Hawaii School of Public Health Honolulu, HI
3The East-West Center, Honolulu, HI
4Department of Internal Medicine, University of Hawaii School of Medicine Honolulu, HI
5United States Department of Veterans Affairs Honolulu, HI
6National Institute on Aging, National Institutes of Health Honolulu, HI
7Department of Tropical Medicine, University of Hawaii School of Medicine Honolulu, HI
Reprint requests to Dr. David M. Morens, Epidemiology Program, University of Hawaii, School of Public Health, Biomed D103, 1960 East-West Road, Honolulu, HI 96822.
Uric acid, an antioxidant found in high concentrations in serum and in the brain, has been hypothesized to protect against oxidative damage and cell death in Parkinson's disease. The authors tested this hypothesis among men participating in a 30-year prospective study known as the Honolulu Heart Program. Serum uric acid was measured in 7, 968 men at the baseline examination held from 1965 to 1968. Of these men, 92 subsequently developed idiopathic Parkinson's disease (IPD). In analyses adjusted for age and smoking, men with uric acid concentrations above the median at enrollment had a 40% reduction in IPD incidence (rate ratio (RR) = 0.6; 95% confidence interval (CI) 0.4–1.0). Reduced IPD incidence rates persisted in analyses restricted to nonsmokers (RR = 0.5; 95% Cl 0.3–1.0) and cases younger than age 75 years (RR = 0.5; 95% Cl 0.3–0.9). Incidence rates were not notably affected when analyses were restricted to cases that occurred more than 5 years after uric acid measurement (RR = 0.6; 95% Cl 0.4–1.0). Inclusion of known or computed correlates of uric acid in regression models did not substantially change risk of IPD. This study provides prospective evidence of an association between uric acid and reduced occurrence of IPD and indicates that further investigations of this association are warranted. Am J Epidemiol 1996; 144: 480-4.
mortality; Parkinson's disease; uric acid
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