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American Journal of Epidemiology Vol. 144, No. 3: 300-305
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health


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Population-based Recurrence Risk of Sudden Infant Death Syndrome Compared with Other Infant and Fetal Deaths

Nina Øyen1,3,, Rolv Skjaerven1,2 and Lorentz M. Irgens1,3

1Medical Birth Registry of Norway, University of Bergen and National Institute of Public Health Norway
2Section for Medical Informatics and Statistics, University of Bergen, Norway
3Division for Preventive Medidne, Department of Public Health and Primary Health Care, University of Bergen, Norway

Reprint requests to Dr. Nina Øyen, Medical Birth Registry of Norway, University of Bergen, Armauer Hansen Building, Haukeland Hospital, N-5021 Bergen, Norway.

To investigate the recurrence of sudden infant death syndrome (SIDS) among siblings, the authors analyzed data for all 352, 475 mothers whose first and second single births were reported to the Medical Birth Registry of Norway during 1967–1988. Recurrence of stillbirths from the 16th week of gestation onward and infant deaths other than SIDS were also studied. Relative risk of recurrence for SIDS was 5.8 (95% confidence interval (Cl) 2.1–13.2); for asphyxia- and immaturity-related infant deaths, 12.5 (9.2–17.4); for congenital malformations, 7.2 (4.7–11.0); and for other causes of infant death, 8.0 (2.0–22.1). Deaths due to infections did not recur. Similar categories of infant deaths had higher overall relative risk, 9.1, compared with 1.6 for dissimilar categories. Previous early stillbirth (16–27 weeks) had a high recurrence (relative risk (RR) = 21.8, 95% Cl 17.5–26.9), while late stillbirth (≥28 weeks) had lower recurrence (RR = 4.6, 95% Cl 3.7–5.8). Previous SIDS was associated with an increased risk of all other types of loss. In contrast, previous late stillbirth and previous asphyxia- and immaturity-related infant deaths were associated with a reduced risk of subsequent SIDS (RR = 0.31, 95% Cl 0.08–0.84, and RR = 0.23, 95% Cl 0.01–1.13, respectively). In conclusion, as with other infant and fetal deaths, SIDS deaths showed strong sibship aggregation consistent with a genetic susceptibility in subsets of SIDS that may interact with environmental factors. The authors also suggest common pregnancy-specific risk factors for late stillbirths, asphyxia- and immaturity-related infant deaths, and SIDS. Am J Epidemiol 1996; 144: 300–5.

fetal death; genetics; infant mortality; infant, premature; population; recurrence; risk; sudden infant death


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