American Journal of Epidemiology Vol. 144, No. 10: 916-923
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
other |
Increased Incidence of Cancer among Homosexual Men, New York City and San Francisco, 1978–1990
1The Wolf Szmuness Laboratory of Epidemiology, The New York Blood Center New York, NY
2Department of Medicine, University of California San Francisco San Francisco, CA
3Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, CA
4Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center sNew York, NY
5AIDS Office, San Francisco Department of Public Health San Francisco, CA
Reprint requests to Dr. Beryl A. Koblin, Laboratory of Epidemiology, The New York Blood Center, 310 E. 67th Street, New York, NY 10021.
Several studies have shown that human immunodeficiency virus type 1 (HIV-1) is associated with an increase in the incidence of Kaposi's sarcoma and non-Hodgkin's lymphoma among homosexual men. The role of HIV-1 in increasing the incidence of other malignancies is more controversial. The incidence of non-Kaposi's sarcoma cancer was examined from 1978 to 1990 among 15, 565 homosexual men who participated in studies of hepatitis B virus infection in the late 1970s in New York City, New York, and San Francisco, California. The standardized incidence ratio (SIR) for all cancers was 1.6 (95% confidence interval (Cl) 1.4–1.8). Excesses were observed for non-Hodgkin's lymphoma (SIR = 12.7; 95% Cl 11.0–14.6), Hodgkin's disease (SIR = 2.5; 95% Cl 1.5–3.9), and anal cancer (SIR = 24.2; 95% Cl 13.5–39.9). As seen with non-Hodgkin's lymphoma, a cancer known to be associated with HIV-1, Hodgkin's disease incidence was significantly higher in more recent years compared with earlier years. No cases of Hodgkin's disease were found among HIV-1 antibody-negative men, and Hodgkin's disease was diagnosed near the time of initial acquired immunodeficiency syndrome diagnoses. Anal cancer incidence did not correlate with HIV-1 antibody status and did not tend to occur near the time of AIDS diagnoses. This study confirms the association of non-Hodgkin's lymphoma with HIV-1 infection and suggests an association between Hodgkin's disease and HIV-1 infection. An excess in anal cancer was observed but did not appear to be associated with HIV-1 infection. Am J Epidemiol 1996; 144: 916-23.
acquired immunodeficiency syndrome; HIV; HIV-related lymphoma; Hodgkin's disease; homosexuality; neoplasms
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. J. Biggar, E. S. Jaffe, J. J. Goedert, A. Chaturvedi, R. Pfeiffer, E. A. Engels, and for the HIV/AIDS Cancer Match Study Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS Blood, December 1, 2006; 108(12): 3786 - 3791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lewden, D. Salmon, P. Morlat, S. Bevilacqua, E. Jougla, F. Bonnet, L. Heripret, D. Costagliola, T. May, G. Chene, et al. Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS Int. J. Epidemiol., February 1, 2005; 34(1): 121 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Herida, M. Mary-Krause, R. Kaphan, J. Cadranel, I. Poizot-Martin, C. Rabaud, N. Plaisance, H. Tissot-Dupont, F. Boue, J.-M. Lang, et al. Incidence of Non-AIDS-Defining Cancers Before and During the Highly Active Antiretroviral Therapy Era in a Cohort of Human Immunodeficiency Virus-Infected Patients J. Clin. Oncol., September 15, 2003; 21(18): 3447 - 3453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Frisch, E. Smith, A. Grulich, and C. Johansen Cancer in a Population-based Cohort of Men and Women in Registered Homosexual Partnerships Am. J. Epidemiol., June 1, 2003; 157(11): 966 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Staley, W. Hussey, K. Roe, J. Harcourt, and K. Roe In the Shadow of the Rainbow: Identifying and Addressing Health Disparities in the Lesbian, Gay, Bisexual, and Transgender Population-- a Research and Practice Challenge Health Promot Pract, July 1, 2001; 2(3): 207 - 211. [PDF]
|
|
|
|
 |
|
 M. Frisch, R. J. Biggar, E. A. Engels, J. J. Goedert, and for the AIDS-Cancer Match Registry Study Group Association of Cancer With AIDS-Related Immunosuppression in Adults JAMA, April 4, 2001; 285(13): 1736 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Frisch, R. J. Biggar, and J. J. Goedert Human Papillomavirus-Associated Cancers in Patients With Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome J Natl Cancer Inst, September 20, 2000; 92(18): 1500 - 1510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Goldie, K. M. Kuntz, M. C. Weinstein, K. A. Freedberg, M. L. Welton, and J. M. Palefsky The Clinical Effectiveness and Cost-effectiveness of Screening for Anal Squamous Intraepithelial Lesions in Homosexual and Bisexual HIV-Positive Men JAMA, May 19, 1999; 281(19): 1822 - 1829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Wool AIDS-Related Malignancies Oncologist, August 1, 1998; 3(4): 279 - 283. [Full Text]
|
|
|
|
 |
|
 C. S. Rabkin Association of Non-Acquired Immunodeficiency Syndrome-Defining Cancers With Human Immunodeficiency Virus Infection J Natl Cancer Inst Monographs, April 1, 1998; 1998(23): 23 - 25. [Abstract] [Full Text]
|
|