American Journal of Epidemiology Vol. 144, No. 1: 34-41
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
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Plasma Ferrtin, Iron Intake, and the Risk of Colorectal Polyps
1Department of Preventive Medicine, School of Medicine, University of Southern California Los Angeles, CA
2Department of Community Health Sciences, School of Public Health, University of California Los Angeles, CA
3Division of Preventive Medicine, Department of Medicine, University of Alabama Birmingham, AL
4Division of Gastroenterology, Kaiser Permanente Medical Center Los Angeles, CA
5Division of Gastroenterology, Kaiser Permanente Medical Center Bellflower, CA
6Department of Epidemiology, School of Public Health, University of California Los Angeles, CA
Reprint requests to Dr. Robert W. Haile, Department of Preventive Medicine, School of Medicine, University of Southern California, Parkview Medical Building Room B106B, 1420 San Pablo Street, Los Angeles, CA 90033.
High iron exposure has been associated with colorectal neoplasia in several studies. The authors investigated plasma ferritin, an indicator of iron stores, and iron intake as risk factors for adenomatous polyps, intermediate markers for colorectal cancer. During 1991–1993, they collected fasting blood samples from and administered questionnaires to men and women 50–75 years old who visited free sigmoidoscopy clinics at a health maintenance organization. Data from 965 subjects (467 cases, 498 controls) were analyzed. Compared with those who had low-normal plasma ferritin concentrations (73–141 µg/liter), those with elevated concentrations (>289 µg/liter) had a multivariate-adjusted odds ratio of 1.5 (95% confidence interval (Cl) 1.0–2.3) after excluding subjects with possible non-iron-related elevations in ferritin. Compared with subjects consuming an adequate amount of iron (11.6–13.6 mg/day), multivariate-adjusted odds ratios were 1.6 (95% Cl 1.1–2.4) for <11.6 mg/day and 1.4 (95% Cl 0.9–2.0) for >27.3 mg/day. These results provide further support for a weak positive association between iron exposure and colorectal polyps. Am J Epidemiol 1996; 144: 34–41.
colonic polyps; colorectal neoplasms; ferritin; iron
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