American Journal of Epidemiology Vol. 143, No. 7: 698-706
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
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Body Size and Breast Cancer Risk among Women under Age 45 Years
1Environmental Epidemiology Branch, National Cancer Institute Bethesda, MD
2Department of Epidemiology, Rollins School of Public Hearth, Emory University Atlanta, GA
3Special Epidemiology Program, New Jersey State Department of Hearth Trenton, NJ
4Fred Hutchinson Cancer Research Center Seattle, WA
5Division of Epidemiology, Columbia University School of Public Heath New York, NY
6 Otney, MD
Reprint requests to Dr. Christine A. Swanson, Nutritional Epidemiology Section, Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPN Room 443, 6130 Executive Blvd., MSC 7374, Bethesda, MD 20892.
In a multicenter population-based case-control study that included 1,588 cases and 1,394 controls less than age 45 years, the authors examined the relation of adult body size and breast cancer risk among young women. Breast cancer patients and healthy controls were identified in Atlanta, Georgia; Seattle/Puget Sound, Washington; and central New Jersey. Cases were newly diagnosed with in situ or invasive breast cancer during the period of May 1, 1990, through December 31, 1992. Anthropometric variables thought to reflect early environmental factors (e.g., height, sitting height, frame size), obesity, and body fat distribution were measured directly. Height, but not sitting height or frame size, was a breast cancer risk factor. Risk of the disease was increased 46 percent among women in the fourth quartile of height (>167 cm) compared with women in the first quartile (<159 cm). Body weight, but not body fat distribution, was related to breast cancer risk. Risk of the disease was 35 percent lower among women in the highest quartile of Quetelet index (>28.8 kg/m2) compared with women in the lowest quartile (<22.0 kg/m2). Risk of the disease was increased about 2.1-fold (95 percent confidence interval 1.2–3.8) among women who were thin and tall compared with women who were heavy and short. Thus, breast cancer risk was increased substantially among younger women with a linear body type.
anthropometry; body height; body weight; breast neoplasms
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