American Journal of Epidemiology Vol. 143, No. 6: 570-577
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
other |
Pre- and Perinatal Risk Factors for Asthma in Inner City African-American Children
1Rainbow Babies and Children's Hospital, University Hospitals, Case Western Reserve University Cleveland, OH
2VA Medical Center, Case Western Reserve University Cleveland, OH
Reprint requests to Dr. Susan Redline, Cleveland VA Medical Center, 10701 East Blvd. 111J(W), Cleveland, OH 44122.
The relations between pre- and perinatal risk factors and asthma were investigated using a case-control study of 262 African-American children aged 4–9 years, both asthmatic and nonasthmatic, all of whom resided in a poor urban area and received health care at a local hospital-based clinic. Risk factors were ascertained through review of obstetric, perinatal, and pediatric records. Asthmatic children had significantly lower birth weights and gestational ages than nonasthmatic children and were more likely to have required oxygen supplementation and positive pressure ventilation after birth than nonasthmatics (p<0.05). The mothers of asthmatic children were more likely to have smoked during pregnancy (50% vs. 27%), to have gained less weight during pregnancy (26.3 pounds (11.9 kg) vs. 34.5 pounds (15.7 kg)), and to have had no prenatal care (12% vs. 2%) than mothers of nonasthmatic children. Multiple logistic regression demonstrated that the strongest independent predictors of asthma were maternal history of asthma (adjusted odds ratio (OR) = 9.7), lack of prenatal care (OR = 4.7), history of bronchiolitis (OR = 4.7), positive pressure ventilation at birth (OR = 3.3), low maternal weight gain (<20 pounds (<9 kg)) (OR = 3.4), and maternal smoking during pregnancy (OR = 2.8). These data suggest that pre- and perinatal exposures may increase susceptibility to asthma in inner city children.
asthma; blacks; child; prenatal care; prenatal exposure delayed effects; risk factors
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M-J. Martel, E. Rey, M-F. Beauchesne, J-L. Malo, S. Perreault, A. Forget, and L. Blais Control and severity of asthma during pregnancy are associated with asthma incidence in offspring: two-stage case-control study Eur. Respir. J., September 1, 2009; 34(3): 579 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Villamor, A. Iliadou, and S. Cnattingius Is the Association Between Low Birth Weight and Asthma Independent of Genetic and Shared Environmental Factors? Am. J. Epidemiol., June 1, 2009; 169(11): 1337 - 1343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Martel, E. Rey, J.-L. Malo, S. Perreault, M.-F. Beauchesne, A. Forget, and L. Blais Determinants of the Incidence of Childhood Asthma: A Two-Stage Case-Control Study Am. J. Epidemiol., January 15, 2009; 169(2): 195 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J S Halterman, K A Lynch, K M Conn, T E Hernandez, T T Perry, and T P Stevens Environmental exposures and respiratory morbidity among very low birth weight infants at 1 year of life Arch. Dis. Child., January 1, 2009; 94(1): 28 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Nepomnyaschy and N. E. Reichman Low Birthweight and Asthma Among Young Urban Children Am J Public Health, September 1, 2006; 96(9): 1604 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Potts and C. B. Reagan Thinking Outside the Inhaler: Potential Barriers to Controlled Asthma in Children Journal of Pharmacy Practice, June 1, 2004; 17(3): 211 - 220. [Abstract] [PDF]
|
|
|
|
 |
|
 M. D. Klinnert, M. R. Price, A. H. Liu, and J. L. Robinson Morbidity Patterns Among Low-Income Wheezing Infants Pediatrics, July 1, 2003; 112(1): 49 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Bracken, K. Belanger, W. O. Cookson, E. Triche, D. C. Christiani, and B. P. Leaderer Genetic and Perinatal Risk Factors for Asthma Onset and Severity: A Review and Theoretical Analysis Epidemiol. Rev., December 1, 2002; 24(2): 176 - 189. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Yuan, O. Basso, H. T Sorensen, and J. Olsen Fetal growth and hospitalization with asthma during early childhood: a follow-up study in Denmark Int. J. Epidemiol., December 1, 2002; 31(6): 1240 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Klinnert, M. R. Price, A. H. Liu, and J. L. Robinson Unraveling the Ecology of Risks for Early Childhood Asthma Among Ethnically Diverse Families in the Southwest Am J Public Health, May 1, 2002; 92(5): 792 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Klinnert, H. S. Nelson, M. R. Price, A. D. Adinoff, D. Y. M. Leung, and D. A. Mrazek Onset and Persistence of Childhood Asthma: Predictors From Infancy Pediatrics, October 1, 2001; 108(4): e69 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Brooks, R. S. Byrd, M. Weitzman, P. Auinger, and J. T. McBride Impact of Low Birth Weight on Early Childhood Asthma in the United States Arch Pediatr Adolesc Med, March 1, 2001; 155(3): 401 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C E Lopuhaä, T J Roseboom, C Osmond, D J P Barker, A C J Ravelli, O P Bleker, J S van der Zee, and J H P van der Meulen Atopy, lung function, and obstructive airways disease after prenatal exposure to famine Thorax, July 1, 2000; 55(7): 555 - 561. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. E. Gern and S. T. Weiss Protection Against Atopic Diseases by Measles--A Rash Conclusion? JAMA, January 19, 2000; 283(3): 394 - 395. [Full Text] [PDF]
|
|
|
|
|
|
P. Leadbitter, N. Pearce, S. Cheng, M. R Sears, M D. Holdaway, E. M Flannery, G P. Herbison, and R. Beasley Relationship between fetal growth and the development of asthma and atopy in childhood Thorax, October 1, 1999; 54(10): 905 - 910. [Abstract] [Full Text]
|
|
|
|
|
|
C. E Donovan and P. W Finn Immune mechanisms of childhood asthma Thorax, October 1, 1999; 54(10): 938 - 946. [Full Text]
|
|
|
|
|
|
S. L. Stathis, D.&H*; M. O'Callaghan, G. M. Williams, J. M. Najman, M. J. Andersen, and A.{p. a. W. Bor Maternal Cigarette Smoking During Pregnancy Is an Independent Predictor for Symptoms of Middle Ear Disease at Five Years' Postdelivery Pediatrics, August 1, 1999; 104(2): 16e - 16. [Abstract] [Full Text]
|
|
|
|
|
|
D. P Strachan and D. G Cook Parental smoking and childhood asthma: longitudinal and case-control studies Thorax, March 1, 1998; 53(3): 204 - 212. [Abstract] [Full Text]
|
|
|
|
|
|
R. F. Lemanske Jr and W. W. Busse Asthma JAMA, December 10, 1997; 278(22): 1855 - 1873. [Abstract] [PDF]
|
|