American Journal of Epidemiology Vol. 143, No. 4: 363-373
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
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Occupational Risk Factors for Prostate Cancer: Results from a Case-Control Study in Montréal, Québec, Canada
1Preventive Medicine and Biostatistics, University of Toronto Toronto, Ontario, Canada.
2Epidemiology and Biostatistics Unit, Institut Armand-Frappler Laval, Québec, Canada.
3Department of Epidemiology and Biostatistics, McGill University, Montréal Québec, Canada.
4Département de Médecine du Travail, Université de Montréal Montréal, Québec, Canada
Reprint requests to Dr. Kristan Aronson, Department of Community Health and Epidemiology, Queen's University, Kingston, Ontario, Canada K7L 3N6.
A population-based case-control study of cancer and occupation was carried out in Montréal, Canada. Between 1979 and 1986, 449 pathologically confirmed cases of prostate cancer were interviewed, as well as 1,550 cancer controls and 533 population controls. Job histories were evaluated by a team of chemist/hygienists using a checklist of 294 workplace chemicals. After preliminary evaluation, 17 occupations, 11 industries, and 27 substances were selected for multivanate logistic regression analyses to estimate the odds ratio between each occupational circumstance and prostate cancer with control for potential confounders. There was moderate support for risk due to the following occupations: electrical power workers, water transport workers, aircraft fabricators, metal product fabricators, structural metal erectors, and railway transport workers. The following substances exhibited moderately strong associations: metallic dust, liquid fuel combustion products, lubricating oils and greases, and polyaromatic hydrocarbons from coal. While the population attributable risk, estimated at between 12% and 21% for these occupational exposures, may be an overestimate due to our method of analysis, even if the true attributable fraction were in the range of 5–10%, this represents an important public health issue.
carcinogens; fossil fuels; industrial oils; metals; occupational exposure; prostatic neoplasms; risk factors
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