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American Journal of Epidemiology Vol. 143, No. 3: 278-282
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Temporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992

Noya Galai1, Alessandro Cozzi Lepri2, David Vlahov1, Patrizio Pezzotti2, Alessandro Sinicco3, Giovanni Rezza2, and Human Immunodeficiency Virus Italian Seroconversion Study 4

1Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University Baltimore, MD
2Centro Operativo AIDS, Istituto Superiore Di Sanitá Rome, Italy
3Clinica Malattie Infettive, Ospedale Amedeo di Savola Torino, Italy

Reprint requests to Dr. Giovanni Rezza, V. Regina Elena, 299, 00166, Rome, Italy.

To determine whether initial CD4 cell counts after human immunodeficiency virus (HIV) seroconversion have decreased over calendar time among participants in the Italian Seroconversion Study, HIV seroconverters who between 1985 and 1992 had a documented negative serology followed by a positive serology within 12 months and a first CD4 cell measurement within 24 months of seroconversion (defined as midpoint of negative and positive HIV tests) were cross-tabulated by year of seroconversion. Linear regression methods were used to examine temporal trends in initial CD4 level after adjustment for age, lag time of seroconversion, lag time of CD4 cell measurement, risk group, and clinical center. Between 1985 and 1992, the overall median initial CD4 cell level after seroconversion was 660 µl with a median lag time of 212 days and 137 days for seroconversion and first CD4 cell measurement, respectively. In univariate and multivariate models, the CD4 cell count increases of 4.3 and 4.2 cells µl/year, respectively, were not statistically significant. These data do not identify a trend of lower CD4 counts following HIV seroconversion in Italy and suggest indirectly that HIV has probably not become more virulent between 1985 and 1992.

HIV; incidence; substance abuse,intravenous

4The HIV-ISS also includes: G. Angarano (Clinica Malattie Infettive, Bari); F. Castelli (Ospedale Civile di Brescia); P. Viale (Ospedale Civite di Piacenza); B. Salassa (Ospedale Amedeo di Savoia, Torino); E. Ricchi (Clinica Malattie Infettive, Bologna); M. Barbanera (Ospedale Rluniti, Livorno); L Ortona (Universitá Cattolica, Rome); U. Tirelli (Centro di Riferimento Oncologico, Aviano); F. Aluti (Universitá La Sapienza, Rome); A. Canessa (Ospendale S. Martino, Genoa); S. Muratori (I Clinica Dermatologica, Centro Ant-Venereo, Milan); M. Zaccarelli (Ospendale Spallanzani, Rome); A. Lazzarin (Ospedale San Raffaele, Milan); B. Alliegro and M. Dorrucci (Istituto Superiore di Sanitá, Rome)


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