Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (27)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Andersen, L. P.
Right arrow Articles by Jørgensen, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andersen, L. P.
Right arrow Articles by Jørgensen, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 143, No. 11: 1157-1164
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health

other

Seroprevalence of Immunoglobulin G, M, and A Antibodies to Helicobacter pylori in an Unselected Danish Population

Leif Percival Andersen1,2, Steffen Jais Rosenstock3,4,, Olaf Bonnevie5 and Torben Jørgensen3,4

1Department of Clinical Microbiology, Rigshospitalet, National University Hospital Copenhagen, Denmark
2Department of Clinical Microbiology, Hillerød Hospital Hillerød, Denmark
3The Glostrup Population Studies, Department of Internal Medicine C, Glostrup Hospital, University of Copenhagen Denmark
4Department of Surgery K, Bispebjerg Hospital, University of Copenhagen Copenhagen, Denmark
5Department of Gastroenterology B, Fredenksberg Hosprtal, University of Copenhagen Frederiksberg, Denmark

Reprint requests to Dr. Steffen Rosenstock, Department of Surgery K, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 NV, Copenhagen, Denmark.

The seroprevalences of increased levels of immunoglobulin G (IgG), M (IgM), and A (IgA) antibodies to Helicobacter pylori were assessed by enzyme-linked immunosorbent assay techniques in 3, 589 Danes who participated in a population study in Copenhagen County in 1982. A total of 33.9% of the study population had one or more classes of increased antibodies to H. pylori. Increased levels of IgG, IgM, and IgA antibodies to H. pylori were seen in 25.9% (95% confidence interval (CO 24.5–27.3), 4.5% (95% Cl 2.2–7.0), and 12.0% (95% Cl 10.9–13.1) of the participants, respectively. Women were significantly more likely than men to be seropositive for IgM antibodies (Mantel-Haenszel summary odds ratio = 1.85, 95% Cl 1.34–2.57). Sero-positivrty for IgM antibodies to H. pylori was found less often with increasing age. An IgG antibody response was not seen in 23.7% of cases with overall increased antibodies to H. pylon. Increased levels of IgG or IgA antibodies were more frequent in people with a history of peptic ulcer disease. Seroprevalences of increased H. pylori antibodies are high in unselected populations. Primary H. pylori infections are contracted at all ages, but infection rates decline with age. Inclusion of measurements of IgA and IgM antibody levels in future screening for H. pylori may improve the diagnostic sensitivity of serologic analyses. Am J Epidemiol 1996; 143: 1157–64.

Helicobacter pylori; immunoglobulins; peptic ulcer; prevalence; seroepidemiologic methods


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J OphthalmolHome page
S.-B. Lee, J.-W. Yang, and C.-S. Kim
The association between conjunctival MALT lymphoma and Helicobacter pylori
Br J Ophthalmol, April 1, 2008; 92(4): 534 - 536.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Z. Z. Nurgalieva, M. E. Conner, A. R. Opekun, C. Q. Zheng, S. N. Elliott, P. B. Ernst, M. Osato, M. K. Estes, and D. Y. Graham
B-Cell and T-Cell Immune Responses to Experimental Helicobacter pylori Infection in Humans
Infect. Immun., May 1, 2005; 73(5): 2999 - 3006.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
H J Windle, Y S Ang, V A Morales, R McManus, and D Kelleher
Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals
Gut, January 1, 2005; 54(1): 25 - 32.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S Rosenstock, T Jorgensen, O Bonnevie, and L Andersen
Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults
Gut, February 1, 2003; 52(2): 186 - 193.
[Abstract] [Full Text] [PDF]

Home page
 J. Epidemiol. Community HealthHome page
S. Rosenstock, T. Jorgensen, L. Andersen, and O. Bonnevie
Seroconversion and seroreversion in IgG antibodies to Helicobacter pylori: a serology based prospective cohort study
J Epidemiol Community Health, June 1, 2000; 54(6): 444 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Scand J Public HealthHome page
S. J. Rosenstock, T. Jorgensen, L. P. Andersen, and O. Bonnevie
Association of Helicobacter pylori infection with lifestyle, chronic disease, body-indices, and age at menarche in Danish adults
Scand J Public Health, January 1, 2000; 28(1): 32 - 40.
[Abstract] [PDF]

Home page
 GutHome page
S Rosenstock, L Kay, C Rosenstock, L P Andersen, O Bonnevie, and T Jorgensen
Relation between Helicobacter pylori infection and gastrointestinal symptoms and syndromes
Gut, August 1, 1997; 41(2): 169 - 176.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.