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American Journal of Epidemiology Vol. 143, No. 11: 1107-1115
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health

other

White Blood Cell Counts in Persons Aged 65 Years or More from the Cardiovascular Health Study

Correlations with Baseline Clinical and Demographic Characteristics

Edwin G. Bovill1, Diane E. Bild2, Gerardo Heiss3, Lewis H. Kuller4, Marshall H. Lee5, Robert Rock6 and Patricia W. Wahl7

1Department of Pathology, College of Medicine, University of Vermont Burlington, VT
2National Heart, Lung, and Blood Institute Bethesda, MD
3Department of Epidemiology, School of Public Health, University of North Carolina Chapel Hill, NC
4School of Medicine, University of Pittsburgh Pittsburgh, PA
5School of Medicine, University of California at Davis Sacramento, CA
6American Society of Clinical Pathologists Chicago, IL
7Cardiovascular Health Study, School of Public Health, University of Washington Seattle, WA

A higher white blood cell (WBC) count has been shown to be a risk factor for myocardial infarction and stroke in middle-aged populations. This study evaluated the relation between baseline WBC count and other risk factors, as well as subclinical and prevalent disease, in the Cardiovascular Health Study, an epidemiologic study of coronary heart disease and stroke in 5, 201 persons aged 65 years or older. Baseline data were collected over a 12-month period in 1989–1990. WBC counts were statistically significantly higher in people with prevalent and subclinical atherosclerotic cardiovascular disease than in those who were free of disease. WBC counts correlated (p < 0.01) positively with coagulation factors, measures of glucose metabolism, creatinine, smoking, and triglycerides. In contrast, WBC counts correlated negatively with high density lipoprotein cholesterol, forced expiratory volume, forced vital capacity, and height. The correlations between WBC counts and nsk factors were similar in both the entire cohort and the subgroup of persons who had never smoked. The authors conclude that WBC counts in the elderly are associated with prevalent and subclinical atherosclerotic cardiovascular disease, as well as its risk factors. Am J Epidemiol 1996; 143: 1107–15.

aged; blood cells; cardiovascular diseases; leukocyte count; risk factors


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